Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans

Opening of the UNC-64/syntaxin closed conformation by UNC-13/Munc13 to form the neuronal SNARE complex is critical for neurotransmitter release. Here the authors show that facilitating the opening of syntaxin enhances exocytosis not only in unc-13 nulls as well as in diverse C. elegans mutants.

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Autores principales: Chi-Wei Tien, Bin Yu, Mengjia Huang, Karolina P. Stepien, Kyoko Sugita, Xiaoyu Xie, Liping Han, Philippe P. Monnier, Mei Zhen, Josep Rizo, Shangbang Gao, Shuzo Sugita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/96e3ef5c27104c518147da2404c45bad
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