Measurement of ocular surface protection under natural blink conditions

Richard Abelson1,2, Keith J Lane3, Endri Angjeli3, Patrick Johnston3, George Ousler3, Douglas Montgomery1 1Arizona State University, 2Statistics and Data Corporation, Tempe, AZ, USA; 3Ora, Inc, Andover, MA, USA Purpose: To evaluate a new method of measuring ocular exposure in the context of a natura...

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Autores principales:	Abelson R, Lane KJ, Angjeli E, Johnston P, Ousler G, Montgomery D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/96e70bd2bd554fd4be8af6320414a48c
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spelling	oai:doaj.org-article:96e70bd2bd554fd4be8af6320414a48c2021-12-02T02:42:01ZMeasurement of ocular surface protection under natural blink conditions1177-54671177-5483https://doaj.org/article/96e70bd2bd554fd4be8af6320414a48c2011-09-01T00:00:00Zhttp://www.dovepress.com/measurement-of-ocular-surface-protection-under-natural-blink-condition-a8336https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Richard Abelson1,2, Keith J Lane3, Endri Angjeli3, Patrick Johnston3, George Ousler3, Douglas Montgomery1 1Arizona State University, 2Statistics and Data Corporation, Tempe, AZ, USA; 3Ora, Inc, Andover, MA, USA Purpose: To evaluate a new method of measuring ocular exposure in the context of a natural blink pattern through analysis of the variables tear film breakup time (TFBUT), interblink interval (IBI), and tear film breakup area (BUA). Methods: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately. TFBUT is measured under forced-stare conditions by an examiner using a stopwatch, while IBI is measured as the subject watches television. The new methodology (video capture manual analysis [VCMA]) involves retrospective analysis of video data of fluorescein-stained eyes taken through a slit lamp while the subject watches television, and provides TFBUT and BUA for each IBI during the 1-minute video under natural blink conditions. The FS and VCMA methods were directly compared in the same set of dry-eye subjects. The VCMA method was evaluated for the ability to discriminate between dry-eye subjects and normal subjects. The VCMA method was further evaluated in the dry eye subjects for the ability to detect a treatment effect before, and 10 minutes after, bilateral instillation of an artificial tear solution. Results: Ten normal subjects and 17 dry-eye subjects were studied. In the dry-eye subjects, the two methods differed with respect to mean TFBUTs (5.82 seconds, FS; 3.98 seconds, VCMA; P = 0.002). The FS variables alone (TFBUT, IBI) were not able to successfully distinguish between the dry-eye and normal subjects, whereas the additional VCMA variables, both derived and observed (BUA, BUA/IBI, breakup rate), were able to successfully distinguish between the dry-eye and normal subjects in a statistically significant fashion. TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects. Conclusion: The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern. Keywords: ocular protection index, tear film breakup time, interblink interval, forced stareAbelson RLane KJAngjeli EJohnston POusler GMontgomery DDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1349-1357 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Abelson R Lane KJ Angjeli E Johnston P Ousler G Montgomery D Measurement of ocular surface protection under natural blink conditions
description	Richard Abelson1,2, Keith J Lane3, Endri Angjeli3, Patrick Johnston3, George Ousler3, Douglas Montgomery1 1Arizona State University, 2Statistics and Data Corporation, Tempe, AZ, USA; 3Ora, Inc, Andover, MA, USA Purpose: To evaluate a new method of measuring ocular exposure in the context of a natural blink pattern through analysis of the variables tear film breakup time (TFBUT), interblink interval (IBI), and tear film breakup area (BUA). Methods: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately. TFBUT is measured under forced-stare conditions by an examiner using a stopwatch, while IBI is measured as the subject watches television. The new methodology (video capture manual analysis [VCMA]) involves retrospective analysis of video data of fluorescein-stained eyes taken through a slit lamp while the subject watches television, and provides TFBUT and BUA for each IBI during the 1-minute video under natural blink conditions. The FS and VCMA methods were directly compared in the same set of dry-eye subjects. The VCMA method was evaluated for the ability to discriminate between dry-eye subjects and normal subjects. The VCMA method was further evaluated in the dry eye subjects for the ability to detect a treatment effect before, and 10 minutes after, bilateral instillation of an artificial tear solution. Results: Ten normal subjects and 17 dry-eye subjects were studied. In the dry-eye subjects, the two methods differed with respect to mean TFBUTs (5.82 seconds, FS; 3.98 seconds, VCMA; P = 0.002). The FS variables alone (TFBUT, IBI) were not able to successfully distinguish between the dry-eye and normal subjects, whereas the additional VCMA variables, both derived and observed (BUA, BUA/IBI, breakup rate), were able to successfully distinguish between the dry-eye and normal subjects in a statistically significant fashion. TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects. Conclusion: The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern. Keywords: ocular protection index, tear film breakup time, interblink interval, forced stare
format	article
author	Abelson R Lane KJ Angjeli E Johnston P Ousler G Montgomery D
author_facet	Abelson R Lane KJ Angjeli E Johnston P Ousler G Montgomery D
author_sort	Abelson R
title	Measurement of ocular surface protection under natural blink conditions
title_short	Measurement of ocular surface protection under natural blink conditions
title_full	Measurement of ocular surface protection under natural blink conditions
title_fullStr	Measurement of ocular surface protection under natural blink conditions
title_full_unstemmed	Measurement of ocular surface protection under natural blink conditions
title_sort	measurement of ocular surface protection under natural blink conditions
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/96e70bd2bd554fd4be8af6320414a48c
work_keys_str_mv	AT abelsonr measurementofocularsurfaceprotectionundernaturalblinkconditions AT lanekj measurementofocularsurfaceprotectionundernaturalblinkconditions AT angjelie measurementofocularsurfaceprotectionundernaturalblinkconditions AT johnstonp measurementofocularsurfaceprotectionundernaturalblinkconditions AT ouslerg measurementofocularsurfaceprotectionundernaturalblinkconditions AT montgomeryd measurementofocularsurfaceprotectionundernaturalblinkconditions
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Measurement of ocular surface protection under natural blink conditions

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