Roles of Microvesicles in Tumor Progression and Clinical Applications

Shuangli Zhu,1 Shiyu Li,1 Ming Yi,1 Ning Li,2 Kongming Wu1,2 1Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou Univ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhu S, Li S, Yi M, Li N, Wu K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	tumor-derived microvesicles metastasis drug resistance cancer vaccine cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/96e9c2b11412481c92268986e7948f39
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:96e9c2b11412481c92268986e7948f39
record_format	dspace
spelling	oai:doaj.org-article:96e9c2b11412481c92268986e7948f392021-12-02T17:57:03ZRoles of Microvesicles in Tumor Progression and Clinical Applications1178-2013https://doaj.org/article/96e9c2b11412481c92268986e7948f392021-10-01T00:00:00Zhttps://www.dovepress.com/roles-of-microvesicles-in-tumor-progression-and-clinical-applications-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Shuangli Zhu,1 Shiyu Li,1 Ming Yi,1 Ning Li,2 Kongming Wu1,2 1Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, People’s Republic of ChinaCorrespondence: Ning LiDepartment of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, People’s Republic of ChinaTel +86-371-65587805Email lining97@126.comKongming WuDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaTel +86-27-69378414Email wukm_lab@163.comAbstract: Microvesicles are extracellular vesicles with diameter ranging from 100 to 1000 nm that are secreted by tumor cells or other cells in the tumor microenvironment. A growing number of studies demonstrate that tumor-derived microvesicles are involved in tumor initiation and progression, as well as drug resistance. In addition, tumor-derived microvesicles carry a variety of immunogenic molecules and inhibit tumor response to immunotherapy; therefore, they can be exploited for use in tumor vaccines. Moreover, because of their high stability, tumor-derived microvesicles extracted from body fluids can be used as biomarkers for cancer diagnosis or assessment of prognosis. Tumor-derived microvesicles can also be deployed to reverse drug resistance of tumor regenerative cells, or to deliver chemotherapeutic drugs and oncolytic adenovirus for the treatment of cancer patients. This review summarizes the general characteristics of tumor-derived microvesicles, focusing on their biological characteristics, their involvement in tumor progression, and their clinical applications.Keywords: tumor-derived microvesicles, metastasis, drug resistance, cancer vaccine, cancerZhu SLi SYi MLi NWu KDove Medical Pressarticletumor-derived microvesiclesmetastasisdrug resistancecancer vaccinecancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 7071-7090 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor-derived microvesicles metastasis drug resistance cancer vaccine cancer Medicine (General) R5-920
spellingShingle	tumor-derived microvesicles metastasis drug resistance cancer vaccine cancer Medicine (General) R5-920 Zhu S Li S Yi M Li N Wu K Roles of Microvesicles in Tumor Progression and Clinical Applications
description	Shuangli Zhu,1 Shiyu Li,1 Ming Yi,1 Ning Li,2 Kongming Wu1,2 1Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, People’s Republic of ChinaCorrespondence: Ning LiDepartment of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450008, People’s Republic of ChinaTel +86-371-65587805Email lining97@126.comKongming WuDepartment of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaTel +86-27-69378414Email wukm_lab@163.comAbstract: Microvesicles are extracellular vesicles with diameter ranging from 100 to 1000 nm that are secreted by tumor cells or other cells in the tumor microenvironment. A growing number of studies demonstrate that tumor-derived microvesicles are involved in tumor initiation and progression, as well as drug resistance. In addition, tumor-derived microvesicles carry a variety of immunogenic molecules and inhibit tumor response to immunotherapy; therefore, they can be exploited for use in tumor vaccines. Moreover, because of their high stability, tumor-derived microvesicles extracted from body fluids can be used as biomarkers for cancer diagnosis or assessment of prognosis. Tumor-derived microvesicles can also be deployed to reverse drug resistance of tumor regenerative cells, or to deliver chemotherapeutic drugs and oncolytic adenovirus for the treatment of cancer patients. This review summarizes the general characteristics of tumor-derived microvesicles, focusing on their biological characteristics, their involvement in tumor progression, and their clinical applications.Keywords: tumor-derived microvesicles, metastasis, drug resistance, cancer vaccine, cancer
format	article
author	Zhu S Li S Yi M Li N Wu K
author_facet	Zhu S Li S Yi M Li N Wu K
author_sort	Zhu S
title	Roles of Microvesicles in Tumor Progression and Clinical Applications
title_short	Roles of Microvesicles in Tumor Progression and Clinical Applications
title_full	Roles of Microvesicles in Tumor Progression and Clinical Applications
title_fullStr	Roles of Microvesicles in Tumor Progression and Clinical Applications
title_full_unstemmed	Roles of Microvesicles in Tumor Progression and Clinical Applications
title_sort	roles of microvesicles in tumor progression and clinical applications
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/96e9c2b11412481c92268986e7948f39
work_keys_str_mv	AT zhus rolesofmicrovesiclesintumorprogressionandclinicalapplications AT lis rolesofmicrovesiclesintumorprogressionandclinicalapplications AT yim rolesofmicrovesiclesintumorprogressionandclinicalapplications AT lin rolesofmicrovesiclesintumorprogressionandclinicalapplications AT wuk rolesofmicrovesiclesintumorprogressionandclinicalapplications
_version_	1718379060881522688

Roles of Microvesicles in Tumor Progression and Clinical Applications

Ejemplares similares