Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits

Rare structural variants may account for a significant fraction of variation in complex traits. Here the authors analyse 14 Drosophila melanogaster genomes and find that structural variants are common, found in functionally important genes, and associated with QTLs.

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Autores principales:	Mahul Chakraborty, J. J. Emerson, Stuart J. Macdonald, Anthony D. Long
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/96ea71b67269422fb3fcaaf4399db70f
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spelling	oai:doaj.org-article:96ea71b67269422fb3fcaaf4399db70f2021-12-02T14:40:20ZStructural variants exhibit widespread allelic heterogeneity and shape variation in complex traits10.1038/s41467-019-12884-12041-1723https://doaj.org/article/96ea71b67269422fb3fcaaf4399db70f2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12884-1https://doaj.org/toc/2041-1723Rare structural variants may account for a significant fraction of variation in complex traits. Here the authors analyse 14 Drosophila melanogaster genomes and find that structural variants are common, found in functionally important genes, and associated with QTLs.Mahul ChakrabortyJ. J. EmersonStuart J. MacdonaldAnthony D. LongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mahul Chakraborty J. J. Emerson Stuart J. Macdonald Anthony D. Long Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
description	Rare structural variants may account for a significant fraction of variation in complex traits. Here the authors analyse 14 Drosophila melanogaster genomes and find that structural variants are common, found in functionally important genes, and associated with QTLs.
format	article
author	Mahul Chakraborty J. J. Emerson Stuart J. Macdonald Anthony D. Long
author_facet	Mahul Chakraborty J. J. Emerson Stuart J. Macdonald Anthony D. Long
author_sort	Mahul Chakraborty
title	Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
title_short	Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
title_full	Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
title_fullStr	Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
title_full_unstemmed	Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
title_sort	structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/96ea71b67269422fb3fcaaf4399db70f
work_keys_str_mv	AT mahulchakraborty structuralvariantsexhibitwidespreadallelicheterogeneityandshapevariationincomplextraits AT jjemerson structuralvariantsexhibitwidespreadallelicheterogeneityandshapevariationincomplextraits AT stuartjmacdonald structuralvariantsexhibitwidespreadallelicheterogeneityandshapevariationincomplextraits AT anthonydlong structuralvariantsexhibitwidespreadallelicheterogeneityandshapevariationincomplextraits
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Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits

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