Fluctuation relations and fitness landscapes of growing cell populations

Abstract We construct a pathwise formulation of a growing population of cells, based on two different samplings of lineages within the population, namely the forward and backward samplings. We show that a general symmetry relation, called fluctuation relation relates these two samplings, independent...

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Autores principales:	Arthur Genthon, David Lacoste
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96eb7db0ddd241ec98cd1eb956a9ba71
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spelling	oai:doaj.org-article:96eb7db0ddd241ec98cd1eb956a9ba712021-12-02T15:32:59ZFluctuation relations and fitness landscapes of growing cell populations10.1038/s41598-020-68444-x2045-2322https://doaj.org/article/96eb7db0ddd241ec98cd1eb956a9ba712020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68444-xhttps://doaj.org/toc/2045-2322Abstract We construct a pathwise formulation of a growing population of cells, based on two different samplings of lineages within the population, namely the forward and backward samplings. We show that a general symmetry relation, called fluctuation relation relates these two samplings, independently of the model used to generate divisions and growth in the cell population. These relations lead to estimators of the population growth rate, which can be very efficient as we demonstrate by an analysis of a set of mother machine data. These fluctuation relations lead to general and important inequalities between the mean number of divisions and the doubling time of the population. We also study the fitness landscape, a concept based on the two samplings mentioned above, which quantifies the correlations between a phenotypic trait of interest and the number of divisions. We obtain explicit results when the trait is the age or the size, for age and size-controlled models.Arthur GenthonDavid LacosteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Arthur Genthon David Lacoste Fluctuation relations and fitness landscapes of growing cell populations
description	Abstract We construct a pathwise formulation of a growing population of cells, based on two different samplings of lineages within the population, namely the forward and backward samplings. We show that a general symmetry relation, called fluctuation relation relates these two samplings, independently of the model used to generate divisions and growth in the cell population. These relations lead to estimators of the population growth rate, which can be very efficient as we demonstrate by an analysis of a set of mother machine data. These fluctuation relations lead to general and important inequalities between the mean number of divisions and the doubling time of the population. We also study the fitness landscape, a concept based on the two samplings mentioned above, which quantifies the correlations between a phenotypic trait of interest and the number of divisions. We obtain explicit results when the trait is the age or the size, for age and size-controlled models.
format	article
author	Arthur Genthon David Lacoste
author_facet	Arthur Genthon David Lacoste
author_sort	Arthur Genthon
title	Fluctuation relations and fitness landscapes of growing cell populations
title_short	Fluctuation relations and fitness landscapes of growing cell populations
title_full	Fluctuation relations and fitness landscapes of growing cell populations
title_fullStr	Fluctuation relations and fitness landscapes of growing cell populations
title_full_unstemmed	Fluctuation relations and fitness landscapes of growing cell populations
title_sort	fluctuation relations and fitness landscapes of growing cell populations
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/96eb7db0ddd241ec98cd1eb956a9ba71
work_keys_str_mv	AT arthurgenthon fluctuationrelationsandfitnesslandscapesofgrowingcellpopulations AT davidlacoste fluctuationrelationsandfitnesslandscapesofgrowingcellpopulations
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Fluctuation relations and fitness landscapes of growing cell populations

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