Screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview

Phuong-Thu T Pham,1 Kari L Edling,2 Harini A Chakkera,3 Phuong-Chi T Pham,4 Phuong-Mai T Pham51Department of Medicine, Nephrology Division, Kidney Transplant Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Department of Medicine, Division of Endocrinology, Diabetes and Hyper...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pham PT, Edling KL, Chakkera HA, Pham PC, Pham PM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/96ec2c6071744f178c166f4d07137722
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:96ec2c6071744f178c166f4d07137722
record_format	dspace
spelling	oai:doaj.org-article:96ec2c6071744f178c166f4d071377222021-12-02T03:33:01ZScreening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview1178-7007https://doaj.org/article/96ec2c6071744f178c166f4d071377222012-10-01T00:00:00Zhttp://www.dovepress.com/screening-strategies-and-predictive-diagnostic-tools-for-the-developme-a11373https://doaj.org/toc/1178-7007Phuong-Thu T Pham,1 Kari L Edling,2 Harini A Chakkera,3 Phuong-Chi T Pham,4 Phuong-Mai T Pham51Department of Medicine, Nephrology Division, Kidney Transplant Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 3Department of Medicine, Nephrology Division Kidney Transplant Program, Mayo Clinic Hospital, Phoenix, AZ, USA; 4Department of Medicine, Nephrology Division, UCLA-Olive View Medical Center, Sylmar, CA, USA; 5Department of Medicine, Greater Los Angeles, Veterans Administration Health Care System, CA, USAAbstract: New-onset diabetes mellitus after transplantation (NODAT) is a serious and common complication following solid organ transplantation. NODAT has been reported in 2% to 53% of all solid organ transplants. Kidney transplant recipients who develop NODAT have variably been reported to be at increased risk of fatal and nonfatal cardiovascular events and other adverse outcomes including infection, reduced patient survival, graft rejection, and accelerated graft loss compared with those who do not develop diabetes. Limited clinical studies in liver, heart, and lung transplants similarly suggested that NODAT has an adverse impact on patient and graft outcomes. Early detection and management of NODAT must, therefore, be integrated into the treatment of transplant recipients. Studies investigating the best screening or predictive tool for identifying patients at risk for developing NODAT early after transplantation, however, are lacking. We review the clinical predictive values of fasting plasma glucose, oral glucose tolerance test, and A1C in assessing the risk for NODAT development and as a screening tool. Simple diabetes prediction models that incorporate clinical and/or metabolic risk factors (such as age, body mass index, hypertriglyceridemia, or metabolic syndrome) are also presented.Keywords: new-onset diabetes after transplantation, impaired fasting glucose, impaired glucose tolerance, oral glucose tolerance test, NODAT screening, diabetes prediction modelsPham PTEdling KLChakkera HAPham PCPham PMDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2012, Iss default, Pp 379-387 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Pham PT Edling KL Chakkera HA Pham PC Pham PM Screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview
description	Phuong-Thu T Pham,1 Kari L Edling,2 Harini A Chakkera,3 Phuong-Chi T Pham,4 Phuong-Mai T Pham51Department of Medicine, Nephrology Division, Kidney Transplant Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 2Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; 3Department of Medicine, Nephrology Division Kidney Transplant Program, Mayo Clinic Hospital, Phoenix, AZ, USA; 4Department of Medicine, Nephrology Division, UCLA-Olive View Medical Center, Sylmar, CA, USA; 5Department of Medicine, Greater Los Angeles, Veterans Administration Health Care System, CA, USAAbstract: New-onset diabetes mellitus after transplantation (NODAT) is a serious and common complication following solid organ transplantation. NODAT has been reported in 2% to 53% of all solid organ transplants. Kidney transplant recipients who develop NODAT have variably been reported to be at increased risk of fatal and nonfatal cardiovascular events and other adverse outcomes including infection, reduced patient survival, graft rejection, and accelerated graft loss compared with those who do not develop diabetes. Limited clinical studies in liver, heart, and lung transplants similarly suggested that NODAT has an adverse impact on patient and graft outcomes. Early detection and management of NODAT must, therefore, be integrated into the treatment of transplant recipients. Studies investigating the best screening or predictive tool for identifying patients at risk for developing NODAT early after transplantation, however, are lacking. We review the clinical predictive values of fasting plasma glucose, oral glucose tolerance test, and A1C in assessing the risk for NODAT development and as a screening tool. Simple diabetes prediction models that incorporate clinical and/or metabolic risk factors (such as age, body mass index, hypertriglyceridemia, or metabolic syndrome) are also presented.Keywords: new-onset diabetes after transplantation, impaired fasting glucose, impaired glucose tolerance, oral glucose tolerance test, NODAT screening, diabetes prediction models
format	article
author	Pham PT Edling KL Chakkera HA Pham PC Pham PM
author_facet	Pham PT Edling KL Chakkera HA Pham PC Pham PM
author_sort	Pham PT
title	Screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview
title_short	Screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview
title_full	Screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview
title_fullStr	Screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview
title_full_unstemmed	Screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview
title_sort	screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/96ec2c6071744f178c166f4d07137722
work_keys_str_mv	AT phampt screeningstrategiesandpredictivediagnostictoolsforthedevelopmentofnewonsetdiabetesmellitusaftertransplantationanoverview AT edlingkl screeningstrategiesandpredictivediagnostictoolsforthedevelopmentofnewonsetdiabetesmellitusaftertransplantationanoverview AT chakkeraha screeningstrategiesandpredictivediagnostictoolsforthedevelopmentofnewonsetdiabetesmellitusaftertransplantationanoverview AT phampc screeningstrategiesandpredictivediagnostictoolsforthedevelopmentofnewonsetdiabetesmellitusaftertransplantationanoverview AT phampm screeningstrategiesandpredictivediagnostictoolsforthedevelopmentofnewonsetdiabetesmellitusaftertransplantationanoverview
_version_	1718401745843912704

Screening strategies and predictive diagnostic tools for the development of new-onset diabetes mellitus after transplantation: an overview

Ejemplares similares