Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design

Inhalation of Calcium Phosphate nanoparticles (CaPs) has recently unmasked the potential of this nanomedicine for a respiratory lung-to-heart drug delivery targeting the myocardial cells. In this work, we investigated the development of a novel highly respirable dry powder embedding crystalline CaPs...

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Autores principales:	Eride Quarta, Fabio Sonvico, Ruggero Bettini, Claudio De Luca, Alessandro Dotti, Daniele Catalucci, Michele Iafisco, Lorenzo Degli Esposti, Gaia Colombo, Giovanna Trevisi, Dimitrios M. Rekkas, Alessandra Rossi, Tin Wui Wong, Francesca Buttini, Paolo Colombo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	calcium phosphate nanoparticles microparticles embedding nanoparticles design of experiment pulmonary delivery Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/96ecb788072c4ea29f9c14e7e96dcf15
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spelling	oai:doaj.org-article:96ecb788072c4ea29f9c14e7e96dcf152021-11-25T18:40:57ZInhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design10.3390/pharmaceutics131118251999-4923https://doaj.org/article/96ecb788072c4ea29f9c14e7e96dcf152021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1825https://doaj.org/toc/1999-4923Inhalation of Calcium Phosphate nanoparticles (CaPs) has recently unmasked the potential of this nanomedicine for a respiratory lung-to-heart drug delivery targeting the myocardial cells. In this work, we investigated the development of a novel highly respirable dry powder embedding crystalline CaPs. Mannitol was selected as water soluble matrix excipient for constructing respirable dry microparticles by spray drying technique. A Quality by Design approach was applied for understanding the effect of the feed composition and spraying feed rate on typical quality attributes of inhalation powders. The in vitro aerodynamic behaviour of powders was evaluated using a medium resistance device. The inner structure and morphology of generated microparticles were also studied. The 1:4 ratio of CaPs/mannitol led to the generation of hollow microparticles, with the best aerodynamic performance. After microparticle dissolution, the released nanoparticles kept their original size.Eride QuartaFabio SonvicoRuggero BettiniClaudio De LucaAlessandro DottiDaniele CatalucciMichele IafiscoLorenzo Degli EspostiGaia ColomboGiovanna TrevisiDimitrios M. RekkasAlessandra RossiTin Wui WongFrancesca ButtiniPaolo ColomboMDPI AGarticlecalcium phosphate nanoparticlesmicroparticles embedding nanoparticlesdesign of experimentpulmonary deliveryPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1825, p 1825 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcium phosphate nanoparticles microparticles embedding nanoparticles design of experiment pulmonary delivery Pharmacy and materia medica RS1-441
spellingShingle	calcium phosphate nanoparticles microparticles embedding nanoparticles design of experiment pulmonary delivery Pharmacy and materia medica RS1-441 Eride Quarta Fabio Sonvico Ruggero Bettini Claudio De Luca Alessandro Dotti Daniele Catalucci Michele Iafisco Lorenzo Degli Esposti Gaia Colombo Giovanna Trevisi Dimitrios M. Rekkas Alessandra Rossi Tin Wui Wong Francesca Buttini Paolo Colombo Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design
description	Inhalation of Calcium Phosphate nanoparticles (CaPs) has recently unmasked the potential of this nanomedicine for a respiratory lung-to-heart drug delivery targeting the myocardial cells. In this work, we investigated the development of a novel highly respirable dry powder embedding crystalline CaPs. Mannitol was selected as water soluble matrix excipient for constructing respirable dry microparticles by spray drying technique. A Quality by Design approach was applied for understanding the effect of the feed composition and spraying feed rate on typical quality attributes of inhalation powders. The in vitro aerodynamic behaviour of powders was evaluated using a medium resistance device. The inner structure and morphology of generated microparticles were also studied. The 1:4 ratio of CaPs/mannitol led to the generation of hollow microparticles, with the best aerodynamic performance. After microparticle dissolution, the released nanoparticles kept their original size.
format	article
author	Eride Quarta Fabio Sonvico Ruggero Bettini Claudio De Luca Alessandro Dotti Daniele Catalucci Michele Iafisco Lorenzo Degli Esposti Gaia Colombo Giovanna Trevisi Dimitrios M. Rekkas Alessandra Rossi Tin Wui Wong Francesca Buttini Paolo Colombo
author_facet	Eride Quarta Fabio Sonvico Ruggero Bettini Claudio De Luca Alessandro Dotti Daniele Catalucci Michele Iafisco Lorenzo Degli Esposti Gaia Colombo Giovanna Trevisi Dimitrios M. Rekkas Alessandra Rossi Tin Wui Wong Francesca Buttini Paolo Colombo
author_sort	Eride Quarta
title	Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design
title_short	Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design
title_full	Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design
title_fullStr	Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design
title_full_unstemmed	Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design
title_sort	inhalable microparticles embedding calcium phosphate nanoparticles for heart targeting: the formulation experimental design
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/96ecb788072c4ea29f9c14e7e96dcf15
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Inhalable Microparticles Embedding Calcium Phosphate Nanoparticles for Heart Targeting: The Formulation Experimental Design

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