MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation.
We recently identified a novel anilinoquinazoline derivative, Q15, as a potent apoptosis inducer in a panel of human cancer cell lines and determined that Q15 targets hCAP-G2, a subunit of condensin II complex, leading to abnormal cell division. However, whether the defect in normal cell division di...
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2013
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oai:doaj.org-article:96eccc392ff24eebad79670f6372d1b22021-11-18T08:53:21ZMIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation.1932-620310.1371/journal.pone.0076774https://doaj.org/article/96eccc392ff24eebad79670f6372d1b22013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24098805/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203We recently identified a novel anilinoquinazoline derivative, Q15, as a potent apoptosis inducer in a panel of human cancer cell lines and determined that Q15 targets hCAP-G2, a subunit of condensin II complex, leading to abnormal cell division. However, whether the defect in normal cell division directly results in cell death remains unclear. Here, we used an mRNA display method on a microfluidic chip to search for other Q15-binding proteins. We identified an additional Q15-binding protein, MIP-2A (MBP-1 interacting protein-2A), which has been reported to interact with MBP-1, a repressor of the c-Myc promoter. Our results indicate that Q15 inhibits the interaction between MIP-2A and MBP-1 as well as the expression of c-Myc protein, thereby inducing cell death. This study suggests that the simultaneous targeting of hCAP-G2 and MIP-2A is a promising strategy for the development of antitumor drugs as a treatment for intractable tumours.Mayuko TokunagaHirokazu ShiheidoNoriko TabataYuko Sakuma-YonemuraHideaki TakashimaKenichi HorisawaNobuhide DoiHiroshi YanagawaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e76774 (2013) |
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Medicine R Science Q Mayuko Tokunaga Hirokazu Shiheido Noriko Tabata Yuko Sakuma-Yonemura Hideaki Takashima Kenichi Horisawa Nobuhide Doi Hiroshi Yanagawa MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation. |
| description |
We recently identified a novel anilinoquinazoline derivative, Q15, as a potent apoptosis inducer in a panel of human cancer cell lines and determined that Q15 targets hCAP-G2, a subunit of condensin II complex, leading to abnormal cell division. However, whether the defect in normal cell division directly results in cell death remains unclear. Here, we used an mRNA display method on a microfluidic chip to search for other Q15-binding proteins. We identified an additional Q15-binding protein, MIP-2A (MBP-1 interacting protein-2A), which has been reported to interact with MBP-1, a repressor of the c-Myc promoter. Our results indicate that Q15 inhibits the interaction between MIP-2A and MBP-1 as well as the expression of c-Myc protein, thereby inducing cell death. This study suggests that the simultaneous targeting of hCAP-G2 and MIP-2A is a promising strategy for the development of antitumor drugs as a treatment for intractable tumours. |
| format |
article |
| author |
Mayuko Tokunaga Hirokazu Shiheido Noriko Tabata Yuko Sakuma-Yonemura Hideaki Takashima Kenichi Horisawa Nobuhide Doi Hiroshi Yanagawa |
| author_facet |
Mayuko Tokunaga Hirokazu Shiheido Noriko Tabata Yuko Sakuma-Yonemura Hideaki Takashima Kenichi Horisawa Nobuhide Doi Hiroshi Yanagawa |
| author_sort |
Mayuko Tokunaga |
| title |
MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation. |
| title_short |
MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation. |
| title_full |
MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation. |
| title_fullStr |
MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation. |
| title_full_unstemmed |
MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation. |
| title_sort |
mip-2a is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/96eccc392ff24eebad79670f6372d1b2 |
| work_keys_str_mv |
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