Regioselective synthesis of C3 alkylated and arylated benzothiophenes

Benzothiophenes are common motifs in bioactive compounds, but selective functionalization at C3 is challenging. Here the authors report a method starting from benzothiophene S-oxides via an interrupted Pummerer reaction, giving access to a range of C3-alkylated and -arylated products.

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Autores principales:	Harry J. Shrives, José A. Fernández-Salas, Christin Hedtke, Alexander P. Pulis, David J. Procter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/96ecf75c80164e3692bef7fa44f24f7a
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spelling	oai:doaj.org-article:96ecf75c80164e3692bef7fa44f24f7a2021-12-02T14:41:21ZRegioselective synthesis of C3 alkylated and arylated benzothiophenes10.1038/ncomms148012041-1723https://doaj.org/article/96ecf75c80164e3692bef7fa44f24f7a2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14801https://doaj.org/toc/2041-1723Benzothiophenes are common motifs in bioactive compounds, but selective functionalization at C3 is challenging. Here the authors report a method starting from benzothiophene S-oxides via an interrupted Pummerer reaction, giving access to a range of C3-alkylated and -arylated products.Harry J. ShrivesJosé A. Fernández-SalasChristin HedtkeAlexander P. PulisDavid J. ProcterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Harry J. Shrives José A. Fernández-Salas Christin Hedtke Alexander P. Pulis David J. Procter Regioselective synthesis of C3 alkylated and arylated benzothiophenes
description	Benzothiophenes are common motifs in bioactive compounds, but selective functionalization at C3 is challenging. Here the authors report a method starting from benzothiophene S-oxides via an interrupted Pummerer reaction, giving access to a range of C3-alkylated and -arylated products.
format	article
author	Harry J. Shrives José A. Fernández-Salas Christin Hedtke Alexander P. Pulis David J. Procter
author_facet	Harry J. Shrives José A. Fernández-Salas Christin Hedtke Alexander P. Pulis David J. Procter
author_sort	Harry J. Shrives
title	Regioselective synthesis of C3 alkylated and arylated benzothiophenes
title_short	Regioselective synthesis of C3 alkylated and arylated benzothiophenes
title_full	Regioselective synthesis of C3 alkylated and arylated benzothiophenes
title_fullStr	Regioselective synthesis of C3 alkylated and arylated benzothiophenes
title_full_unstemmed	Regioselective synthesis of C3 alkylated and arylated benzothiophenes
title_sort	regioselective synthesis of c3 alkylated and arylated benzothiophenes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/96ecf75c80164e3692bef7fa44f24f7a
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Regioselective synthesis of C3 alkylated and arylated benzothiophenes

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