Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma

Abstract Metabolic pattern reconstruction is an important factor in tumor progression. Metabolism of tumor cells is characterized by abnormal increase in anaerobic glycolysis, regardless of high oxygen concentration, resulting in a significant accumulation of energy from glucose sources. These chang...

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Autores principales:	Lingyu Zhang, Yu Li, Yibei Dai, Danhua Wang, Xuchu Wang, Ying Cao, Weiwei Liu, Zhihua Tao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96edcea03242440f800d3dc80273bf5b
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spelling	oai:doaj.org-article:96edcea03242440f800d3dc80273bf5b2021-12-02T18:48:09ZGlycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma10.1038/s41598-021-98381-22045-2322https://doaj.org/article/96edcea03242440f800d3dc80273bf5b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98381-2https://doaj.org/toc/2045-2322Abstract Metabolic pattern reconstruction is an important factor in tumor progression. Metabolism of tumor cells is characterized by abnormal increase in anaerobic glycolysis, regardless of high oxygen concentration, resulting in a significant accumulation of energy from glucose sources. These changes promotes rapid cell proliferation and tumor growth, which is further referenced a process known as the Warburg effect. The current study reconstructed the metabolic pattern in progression of cancer to identify genetic changes specific in cancer cells. A total of 12 common types of solid tumors were included in the current study. Gene set enrichment analysis (GSEA) was performed to analyze 9 glycolysis-related gene sets, which are implicated in the glycolysis process. Univariate and multivariate analyses were used to identify independent prognostic variables for construction of a nomogram based on clinicopathological characteristics and a glycolysis-related gene prognostic index (GRGPI). The prognostic model based on glycolysis genes showed high area under the curve (AUC) in LIHC (Liver hepatocellular carcinoma). The findings of the current study showed that 8 genes (AURKA, CDK1, CENPA, DEPDC1, HMMR, KIF20A, PFKFB4, STMN1) were correlated with overall survival (OS) and recurrence-free survival (RFS). Further analysis showed that the prediction model accurately distinguished between high- and low-risk cancer patients among patients in different clusters in LIHC. A nomogram with a well-fitted calibration curve based on gene expression profiles and clinical characteristics showed good discrimination based on internal and external cohorts. These findings indicate that changes in expression level of metabolic genes implicated in glycolysis can contribute to reconstruction of tumor-related microenvironment.Lingyu ZhangYu LiYibei DaiDanhua WangXuchu WangYing CaoWeiwei LiuZhihua TaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingyu Zhang Yu Li Yibei Dai Danhua Wang Xuchu Wang Ying Cao Weiwei Liu Zhihua Tao Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
description	Abstract Metabolic pattern reconstruction is an important factor in tumor progression. Metabolism of tumor cells is characterized by abnormal increase in anaerobic glycolysis, regardless of high oxygen concentration, resulting in a significant accumulation of energy from glucose sources. These changes promotes rapid cell proliferation and tumor growth, which is further referenced a process known as the Warburg effect. The current study reconstructed the metabolic pattern in progression of cancer to identify genetic changes specific in cancer cells. A total of 12 common types of solid tumors were included in the current study. Gene set enrichment analysis (GSEA) was performed to analyze 9 glycolysis-related gene sets, which are implicated in the glycolysis process. Univariate and multivariate analyses were used to identify independent prognostic variables for construction of a nomogram based on clinicopathological characteristics and a glycolysis-related gene prognostic index (GRGPI). The prognostic model based on glycolysis genes showed high area under the curve (AUC) in LIHC (Liver hepatocellular carcinoma). The findings of the current study showed that 8 genes (AURKA, CDK1, CENPA, DEPDC1, HMMR, KIF20A, PFKFB4, STMN1) were correlated with overall survival (OS) and recurrence-free survival (RFS). Further analysis showed that the prediction model accurately distinguished between high- and low-risk cancer patients among patients in different clusters in LIHC. A nomogram with a well-fitted calibration curve based on gene expression profiles and clinical characteristics showed good discrimination based on internal and external cohorts. These findings indicate that changes in expression level of metabolic genes implicated in glycolysis can contribute to reconstruction of tumor-related microenvironment.
format	article
author	Lingyu Zhang Yu Li Yibei Dai Danhua Wang Xuchu Wang Ying Cao Weiwei Liu Zhihua Tao
author_facet	Lingyu Zhang Yu Li Yibei Dai Danhua Wang Xuchu Wang Ying Cao Weiwei Liu Zhihua Tao
author_sort	Lingyu Zhang
title	Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
title_short	Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
title_full	Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
title_fullStr	Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
title_full_unstemmed	Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
title_sort	glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/96edcea03242440f800d3dc80273bf5b
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_version_	1718377639464402944

Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma

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