Extended embryo culture is effective for patients of an advanced maternal age

Abstract The aim of this study was to determine the effectiveness of extended embryo culture in advanced maternal age (AMA) patients (37–43 years). In this retrospective analysis, 21,301 normally fertilized zygotes from 4952 couples were cultured until the blastocyst stage. Blastocyst development, i...

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Autores principales:	R. Sainte-Rose, C. Petit, L. Dijols, C. Frapsauce, F. Guerif
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96ef476ddb5742068e997bdd4a89d620
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spelling	oai:doaj.org-article:96ef476ddb5742068e997bdd4a89d6202021-12-02T16:31:42ZExtended embryo culture is effective for patients of an advanced maternal age10.1038/s41598-021-92902-92045-2322https://doaj.org/article/96ef476ddb5742068e997bdd4a89d6202021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92902-9https://doaj.org/toc/2045-2322Abstract The aim of this study was to determine the effectiveness of extended embryo culture in advanced maternal age (AMA) patients (37–43 years). In this retrospective analysis, 21,301 normally fertilized zygotes from 4952 couples were cultured until the blastocyst stage. Blastocyst development, including kinetics and morphology, transfer rate, implantation and live birth rates, were measured. In AMA patients, the blastocyst rate was significantly decreased as compared to that in younger women. On day 5, blastocysts underwent growth retardation in AMA patients, which was highlighted by a decreased rate of full/expanded blastocysts. Organization of the cells (trophectoderm and inner cell mass) was unaffected by age. However, in AMA patients, a ‘good’ morphology blastocyst had a decreased probability to implant compared with an ‘average’ morphology blastocyst in younger women. While the rates of blastocyst transfer and useful blastocysts were similar to younger patients, in AMA patients, both implantation and live birth rates were significantly reduced. Our results support the idea that extended embryo culture is not harmful for AMA patients. However, embryo selection allowed by such culture is not powerful enough to avoid chromosomal abnormalities in the developed blastocysts and therefore cannot compensate for the effect of a woman’s age.R. Sainte-RoseC. PetitL. DijolsC. FrapsauceF. GuerifNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q R. Sainte-Rose C. Petit L. Dijols C. Frapsauce F. Guerif Extended embryo culture is effective for patients of an advanced maternal age
description	Abstract The aim of this study was to determine the effectiveness of extended embryo culture in advanced maternal age (AMA) patients (37–43 years). In this retrospective analysis, 21,301 normally fertilized zygotes from 4952 couples were cultured until the blastocyst stage. Blastocyst development, including kinetics and morphology, transfer rate, implantation and live birth rates, were measured. In AMA patients, the blastocyst rate was significantly decreased as compared to that in younger women. On day 5, blastocysts underwent growth retardation in AMA patients, which was highlighted by a decreased rate of full/expanded blastocysts. Organization of the cells (trophectoderm and inner cell mass) was unaffected by age. However, in AMA patients, a ‘good’ morphology blastocyst had a decreased probability to implant compared with an ‘average’ morphology blastocyst in younger women. While the rates of blastocyst transfer and useful blastocysts were similar to younger patients, in AMA patients, both implantation and live birth rates were significantly reduced. Our results support the idea that extended embryo culture is not harmful for AMA patients. However, embryo selection allowed by such culture is not powerful enough to avoid chromosomal abnormalities in the developed blastocysts and therefore cannot compensate for the effect of a woman’s age.
format	article
author	R. Sainte-Rose C. Petit L. Dijols C. Frapsauce F. Guerif
author_facet	R. Sainte-Rose C. Petit L. Dijols C. Frapsauce F. Guerif
author_sort	R. Sainte-Rose
title	Extended embryo culture is effective for patients of an advanced maternal age
title_short	Extended embryo culture is effective for patients of an advanced maternal age
title_full	Extended embryo culture is effective for patients of an advanced maternal age
title_fullStr	Extended embryo culture is effective for patients of an advanced maternal age
title_full_unstemmed	Extended embryo culture is effective for patients of an advanced maternal age
title_sort	extended embryo culture is effective for patients of an advanced maternal age
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/96ef476ddb5742068e997bdd4a89d620
work_keys_str_mv	AT rsainterose extendedembryocultureiseffectiveforpatientsofanadvancedmaternalage AT cpetit extendedembryocultureiseffectiveforpatientsofanadvancedmaternalage AT ldijols extendedembryocultureiseffectiveforpatientsofanadvancedmaternalage AT cfrapsauce extendedembryocultureiseffectiveforpatientsofanadvancedmaternalage AT fguerif extendedembryocultureiseffectiveforpatientsofanadvancedmaternalage
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Extended embryo culture is effective for patients of an advanced maternal age

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