Controlling protein activity by dynamic recruitment on a supramolecular polymer platform

DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the programmability of DNA-mediated protein recruitment.

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Autores principales:	Sjors P. W. Wijnands, Wouter Engelen, René P. M. Lafleur, E. W. Meijer, Maarten Merkx
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/96f21eff2c8d4ad2bfb01b1a20c40bed
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spelling	oai:doaj.org-article:96f21eff2c8d4ad2bfb01b1a20c40bed2021-12-02T17:31:16ZControlling protein activity by dynamic recruitment on a supramolecular polymer platform10.1038/s41467-017-02559-02041-1723https://doaj.org/article/96f21eff2c8d4ad2bfb01b1a20c40bed2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02559-0https://doaj.org/toc/2041-1723DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the programmability of DNA-mediated protein recruitment.Sjors P. W. WijnandsWouter EngelenRené P. M. LafleurE. W. MeijerMaarten MerkxNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sjors P. W. Wijnands Wouter Engelen René P. M. Lafleur E. W. Meijer Maarten Merkx Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
description	DNA-origami allows the precise recruitment of DNA-protein conjugates but lacks the dynamics found in natural protein assemblies. Here the authors present a synthetic polymer platform that combines the dynamics of supramolecular polymers with the programmability of DNA-mediated protein recruitment.
format	article
author	Sjors P. W. Wijnands Wouter Engelen René P. M. Lafleur E. W. Meijer Maarten Merkx
author_facet	Sjors P. W. Wijnands Wouter Engelen René P. M. Lafleur E. W. Meijer Maarten Merkx
author_sort	Sjors P. W. Wijnands
title	Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_short	Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_full	Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_fullStr	Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_full_unstemmed	Controlling protein activity by dynamic recruitment on a supramolecular polymer platform
title_sort	controlling protein activity by dynamic recruitment on a supramolecular polymer platform
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/96f21eff2c8d4ad2bfb01b1a20c40bed
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_version_	1718380686681833472

Controlling protein activity by dynamic recruitment on a supramolecular polymer platform

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