Cell-phone-based platform for biomedical device development and education applications.

In this paper we report the development of two attachments to a commercial cell phone that transform the phone's integrated lens and image sensor into a 350x microscope and visible-light spectrometer. The microscope is capable of transmission and polarized microscopy modes and is shown to have...

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Autores principales:	Zachary J Smith, Kaiqin Chu, Alyssa R Espenson, Mehdi Rahimzadeh, Amy Gryshuk, Marco Molinaro, Denis M Dwyre, Stephen Lane, Dennis Matthews, Sebastian Wachsmann-Hogiu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96f430b564d04e2087e05520d334af0d
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spelling	oai:doaj.org-article:96f430b564d04e2087e05520d334af0d2021-11-18T06:57:53ZCell-phone-based platform for biomedical device development and education applications.1932-620310.1371/journal.pone.0017150https://doaj.org/article/96f430b564d04e2087e05520d334af0d2011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21399693/?tool=EBIhttps://doaj.org/toc/1932-6203In this paper we report the development of two attachments to a commercial cell phone that transform the phone's integrated lens and image sensor into a 350x microscope and visible-light spectrometer. The microscope is capable of transmission and polarized microscopy modes and is shown to have 1.5 micron resolution and a usable field-of-view of 150 x 50 with no image processing, and approximately 350 x 350 when post-processing is applied. The spectrometer has a 300 nm bandwidth with a limiting spectral resolution of close to 5 nm. We show applications of the devices to medically relevant problems. In the case of the microscope, we image both stained and unstained blood-smears showing the ability to acquire images of similar quality to commercial microscope platforms, thus allowing diagnosis of clinical pathologies. With the spectrometer we demonstrate acquisition of a white-light transmission spectrum through diffuse tissue as well as the acquisition of a fluorescence spectrum. We also envision the devices to have immediate relevance in the educational field.Zachary J SmithKaiqin ChuAlyssa R EspensonMehdi RahimzadehAmy GryshukMarco MolinaroDenis M DwyreStephen LaneDennis MatthewsSebastian Wachsmann-HogiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17150 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zachary J Smith Kaiqin Chu Alyssa R Espenson Mehdi Rahimzadeh Amy Gryshuk Marco Molinaro Denis M Dwyre Stephen Lane Dennis Matthews Sebastian Wachsmann-Hogiu Cell-phone-based platform for biomedical device development and education applications.
description	In this paper we report the development of two attachments to a commercial cell phone that transform the phone's integrated lens and image sensor into a 350x microscope and visible-light spectrometer. The microscope is capable of transmission and polarized microscopy modes and is shown to have 1.5 micron resolution and a usable field-of-view of 150 x 50 with no image processing, and approximately 350 x 350 when post-processing is applied. The spectrometer has a 300 nm bandwidth with a limiting spectral resolution of close to 5 nm. We show applications of the devices to medically relevant problems. In the case of the microscope, we image both stained and unstained blood-smears showing the ability to acquire images of similar quality to commercial microscope platforms, thus allowing diagnosis of clinical pathologies. With the spectrometer we demonstrate acquisition of a white-light transmission spectrum through diffuse tissue as well as the acquisition of a fluorescence spectrum. We also envision the devices to have immediate relevance in the educational field.
format	article
author	Zachary J Smith Kaiqin Chu Alyssa R Espenson Mehdi Rahimzadeh Amy Gryshuk Marco Molinaro Denis M Dwyre Stephen Lane Dennis Matthews Sebastian Wachsmann-Hogiu
author_facet	Zachary J Smith Kaiqin Chu Alyssa R Espenson Mehdi Rahimzadeh Amy Gryshuk Marco Molinaro Denis M Dwyre Stephen Lane Dennis Matthews Sebastian Wachsmann-Hogiu
author_sort	Zachary J Smith
title	Cell-phone-based platform for biomedical device development and education applications.
title_short	Cell-phone-based platform for biomedical device development and education applications.
title_full	Cell-phone-based platform for biomedical device development and education applications.
title_fullStr	Cell-phone-based platform for biomedical device development and education applications.
title_full_unstemmed	Cell-phone-based platform for biomedical device development and education applications.
title_sort	cell-phone-based platform for biomedical device development and education applications.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/96f430b564d04e2087e05520d334af0d
work_keys_str_mv	AT zacharyjsmith cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT kaiqinchu cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT alyssarespenson cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT mehdirahimzadeh cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT amygryshuk cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT marcomolinaro cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT denismdwyre cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT stephenlane cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT dennismatthews cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications AT sebastianwachsmannhogiu cellphonebasedplatformforbiomedicaldevicedevelopmentandeducationapplications
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Cell-phone-based platform for biomedical device development and education applications.

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