ACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA

Objective: To determine the accuracy of intraoperative radionuclide scintigraphy for detection of sentinel lymph node (SLN), using 99mTc-Nanocolloids, in patients with early breast carcinoma. Study Design: Cross sectional analytical study. Place and Duration of Study: Nuclear Medical Centre, Arme...

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Autores principales:	Zaigham Salim Dar, Omer bin Abdul Aziz, Tanveer Sajid, Mujahid Khalid Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	carcinoma breast sentinel lymph node Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/96f59a6c473041ecabc20c8886dae4c3
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spelling	oai:doaj.org-article:96f59a6c473041ecabc20c8886dae4c32021-12-01T03:07:11ZACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA0030-96482411-8842https://doaj.org/article/96f59a6c473041ecabc20c8886dae4c32018-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2263/1960https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the accuracy of intraoperative radionuclide scintigraphy for detection of sentinel lymph node (SLN), using 99mTc-Nanocolloids, in patients with early breast carcinoma. Study Design: Cross sectional analytical study. Place and Duration of Study: Nuclear Medical Centre, Armed Forces Institute of Pathology, Rawalpindi and department of Surgery, Pak Emirates Military Hospital, Rawalpindi, from Jul 2012 to Jun 2013. Patients and Methods: After fulfilling the inclusion and exclusion criteria and taking written informed consent, 67 patients of carcinoma breast were enrolled in the study. Each patient was injected with 37 MBq of 99mTc- Nanocolloids, via sub areolar, peri-tumoural route, pre-operatively. SLNs were identified using handheld gamma probe followed by excision biopsy. Patients, then, underwent modified radical mastectomy with dissection of axillary lymph nodes (ALN) and the samples were sent for histopathology. Results: Out of 67 patients, 28 to 77 years of age (mean ± SD of 49.61 ± 11.572 years), 17.9% (12) patients had T1tumour while 82.1% (55) had T2 tumour (mean ± SD of 3.48 cm ± 1.050 cm). Histopathology revealed no metastasis in SLNs as well as ALN of 55.2% (37) patients while 40.3% (27) patients were positive for both. However, in 4.5% (3) patients SLNs were negative for metastasis with positive ALN. Diagnostic accuracy was calculated to be 95.5%, sensitivity 90%, false negative rate 4.5% and negative predictive value 92.5%. Conclusion: Intraoperative radionuclide scintigraphy, using 99mTc-Nanocolloids and handheld gamma probe is a reasonably accurate technique for localization of SLNs in early breast carcinoma.Zaigham Salim DarOmer bin Abdul AzizTanveer SajidMujahid Khalid AliArmy Medical College Rawalpindiarticlecarcinoma breastsentinel lymph nodeMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 5, Pp 1101-1105 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	carcinoma breast sentinel lymph node Medicine R Medicine (General) R5-920
spellingShingle	carcinoma breast sentinel lymph node Medicine R Medicine (General) R5-920 Zaigham Salim Dar Omer bin Abdul Aziz Tanveer Sajid Mujahid Khalid Ali ACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA
description	Objective: To determine the accuracy of intraoperative radionuclide scintigraphy for detection of sentinel lymph node (SLN), using 99mTc-Nanocolloids, in patients with early breast carcinoma. Study Design: Cross sectional analytical study. Place and Duration of Study: Nuclear Medical Centre, Armed Forces Institute of Pathology, Rawalpindi and department of Surgery, Pak Emirates Military Hospital, Rawalpindi, from Jul 2012 to Jun 2013. Patients and Methods: After fulfilling the inclusion and exclusion criteria and taking written informed consent, 67 patients of carcinoma breast were enrolled in the study. Each patient was injected with 37 MBq of 99mTc- Nanocolloids, via sub areolar, peri-tumoural route, pre-operatively. SLNs were identified using handheld gamma probe followed by excision biopsy. Patients, then, underwent modified radical mastectomy with dissection of axillary lymph nodes (ALN) and the samples were sent for histopathology. Results: Out of 67 patients, 28 to 77 years of age (mean ± SD of 49.61 ± 11.572 years), 17.9% (12) patients had T1tumour while 82.1% (55) had T2 tumour (mean ± SD of 3.48 cm ± 1.050 cm). Histopathology revealed no metastasis in SLNs as well as ALN of 55.2% (37) patients while 40.3% (27) patients were positive for both. However, in 4.5% (3) patients SLNs were negative for metastasis with positive ALN. Diagnostic accuracy was calculated to be 95.5%, sensitivity 90%, false negative rate 4.5% and negative predictive value 92.5%. Conclusion: Intraoperative radionuclide scintigraphy, using 99mTc-Nanocolloids and handheld gamma probe is a reasonably accurate technique for localization of SLNs in early breast carcinoma.
format	article
author	Zaigham Salim Dar Omer bin Abdul Aziz Tanveer Sajid Mujahid Khalid Ali
author_facet	Zaigham Salim Dar Omer bin Abdul Aziz Tanveer Sajid Mujahid Khalid Ali
author_sort	Zaigham Salim Dar
title	ACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA
title_short	ACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA
title_full	ACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA
title_fullStr	ACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA
title_full_unstemmed	ACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA
title_sort	accuracy of intraoperative radionuclide scintigraphy for detection of sentinel lymph node using 99mtc labeled nanocolloids in early breast carcinoma
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/96f59a6c473041ecabc20c8886dae4c3
work_keys_str_mv	AT zaighamsalimdar accuracyofintraoperativeradionuclidescintigraphyfordetectionofsentinellymphnodeusing99mtclabelednanocolloidsinearlybreastcarcinoma AT omerbinabdulaziz accuracyofintraoperativeradionuclidescintigraphyfordetectionofsentinellymphnodeusing99mtclabelednanocolloidsinearlybreastcarcinoma AT tanveersajid accuracyofintraoperativeradionuclidescintigraphyfordetectionofsentinellymphnodeusing99mtclabelednanocolloidsinearlybreastcarcinoma AT mujahidkhalidali accuracyofintraoperativeradionuclidescintigraphyfordetectionofsentinellymphnodeusing99mtclabelednanocolloidsinearlybreastcarcinoma
_version_	1718405917610868736

ACCURACY OF INTRAOPERATIVE RADIONUCLIDE SCINTIGRAPHY FOR DETECTION OF SENTINEL LYMPH NODE USING 99MTC LABELED NANOCOLLOIDS IN EARLY BREAST CARCINOMA

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