Asymmetry of the temporal code for space by hippocampal place cells

Abstract Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that t...

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Autores principales:	Bryan C. Souza, Adriano B. L. Tort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96f7696c70f34aa2ba418a46bd4d97e0
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spelling	oai:doaj.org-article:96f7696c70f34aa2ba418a46bd4d97e02021-12-02T12:32:45ZAsymmetry of the temporal code for space by hippocampal place cells10.1038/s41598-017-08609-32045-2322https://doaj.org/article/96f7696c70f34aa2ba418a46bd4d97e02017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08609-3https://doaj.org/toc/2045-2322Abstract Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that the spike timing of place cells couples to theta phase before major increases in firing rate, anticipating the animal’s entrance into the classical, rate-based place field. In contrast, spikes rapidly decouple from theta as the animal leaves the place field and firing rate decreases. Therefore, temporal coding has strong asymmetry around the place field center. We further show that the dynamics of temporal coding along space evolves in three stages as the animal traverses the place field: phase coupling, sharp precession and phase decoupling. These results suggest that independent mechanisms may govern rate and temporal coding.Bryan C. SouzaAdriano B. L. TortNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bryan C. Souza Adriano B. L. Tort Asymmetry of the temporal code for space by hippocampal place cells
description	Abstract Hippocampal place cells convey spatial information through spike frequency (“rate coding”) and spike timing relative to the theta phase (“temporal coding”). Whether rate and temporal coding are due to independent or related mechanisms has been the subject of wide debate. Here we show that the spike timing of place cells couples to theta phase before major increases in firing rate, anticipating the animal’s entrance into the classical, rate-based place field. In contrast, spikes rapidly decouple from theta as the animal leaves the place field and firing rate decreases. Therefore, temporal coding has strong asymmetry around the place field center. We further show that the dynamics of temporal coding along space evolves in three stages as the animal traverses the place field: phase coupling, sharp precession and phase decoupling. These results suggest that independent mechanisms may govern rate and temporal coding.
format	article
author	Bryan C. Souza Adriano B. L. Tort
author_facet	Bryan C. Souza Adriano B. L. Tort
author_sort	Bryan C. Souza
title	Asymmetry of the temporal code for space by hippocampal place cells
title_short	Asymmetry of the temporal code for space by hippocampal place cells
title_full	Asymmetry of the temporal code for space by hippocampal place cells
title_fullStr	Asymmetry of the temporal code for space by hippocampal place cells
title_full_unstemmed	Asymmetry of the temporal code for space by hippocampal place cells
title_sort	asymmetry of the temporal code for space by hippocampal place cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/96f7696c70f34aa2ba418a46bd4d97e0
work_keys_str_mv	AT bryancsouza asymmetryofthetemporalcodeforspacebyhippocampalplacecells AT adrianobltort asymmetryofthetemporalcodeforspacebyhippocampalplacecells
_version_	1718393993122807808

Asymmetry of the temporal code for space by hippocampal place cells

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