Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Junfeng Ban, Yan Zhang, Xin Huang, Guanghan Deng, Dongzhi Hou, Yanzhong Chen, Zhufen Lu Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: Drug delivery carriers can maintain effectiv...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ban J, Zhang Y, Huang X, Deng GH, Hou DZ, Chen YZ, Lu ZF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	ocular drug delivery system local bioavailability dexamethasone eye drop administration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/96f7e2ffba3b45399c0be152f298e202
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:96f7e2ffba3b45399c0be152f298e202
record_format	dspace
spelling	oai:doaj.org-article:96f7e2ffba3b45399c0be152f298e2022021-12-02T03:58:31ZCorneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone1178-2013https://doaj.org/article/96f7e2ffba3b45399c0be152f298e2022017-02-01T00:00:00Zhttps://www.dovepress.com/corneal-permeation-properties-of-a-charged-lipid-nanoparticle-carrier--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Junfeng Ban, Yan Zhang, Xin Huang, Guanghan Deng, Dongzhi Hou, Yanzhong Chen, Zhufen Lu Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: Drug delivery carriers can maintain effective therapeutic concentrations in the eye. To this end, we developed lipid nanoparticles (L/NPs) in which the surface was modified with positively charged chitosan, which engaged in hydrogen bonding with the phospholipid membrane. We evaluated in vitro corneal permeability and release characteristics, ocular irritation, and drug dynamics of modified and unmodified L/NPs in aqueous humor. The size of L/NPs was uniform and showed a narrow distribution. Corneal permeation was altered by the presence of chitosan and was dependent on particle size; the apparent permeability coefficient of dexamethasone increased by 2.7 and 1.8 times for chitosan-modified and unmodified L/NPs, respectively. In conclusion, a chitosan-modified system could be a promising method for increasing the ocular bioavailability of unmodified L/NPs by enhancing their retention time and permeation into the cornea. These findings provide a theoretical basis for the development of effective drug delivery systems in the treatment of ocular disease. Keywords: ocular drug delivery system, local bioavailability, dexamethasone, eye drop administrationBan JZhang YHuang XDeng GHHou DZChen YZLu ZFDove Medical Pressarticleocular drug delivery systemlocal bioavailabilitydexamethasoneeye drop administrationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 1329-1339 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	ocular drug delivery system local bioavailability dexamethasone eye drop administration Medicine (General) R5-920
spellingShingle	ocular drug delivery system local bioavailability dexamethasone eye drop administration Medicine (General) R5-920 Ban J Zhang Y Huang X Deng GH Hou DZ Chen YZ Lu ZF Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
description	Junfeng Ban, Yan Zhang, Xin Huang, Guanghan Deng, Dongzhi Hou, Yanzhong Chen, Zhufen Lu Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China Abstract: Drug delivery carriers can maintain effective therapeutic concentrations in the eye. To this end, we developed lipid nanoparticles (L/NPs) in which the surface was modified with positively charged chitosan, which engaged in hydrogen bonding with the phospholipid membrane. We evaluated in vitro corneal permeability and release characteristics, ocular irritation, and drug dynamics of modified and unmodified L/NPs in aqueous humor. The size of L/NPs was uniform and showed a narrow distribution. Corneal permeation was altered by the presence of chitosan and was dependent on particle size; the apparent permeability coefficient of dexamethasone increased by 2.7 and 1.8 times for chitosan-modified and unmodified L/NPs, respectively. In conclusion, a chitosan-modified system could be a promising method for increasing the ocular bioavailability of unmodified L/NPs by enhancing their retention time and permeation into the cornea. These findings provide a theoretical basis for the development of effective drug delivery systems in the treatment of ocular disease. Keywords: ocular drug delivery system, local bioavailability, dexamethasone, eye drop administration
format	article
author	Ban J Zhang Y Huang X Deng GH Hou DZ Chen YZ Lu ZF
author_facet	Ban J Zhang Y Huang X Deng GH Hou DZ Chen YZ Lu ZF
author_sort	Ban J
title	Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
title_short	Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
title_full	Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
title_fullStr	Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
title_full_unstemmed	Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
title_sort	corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/96f7e2ffba3b45399c0be152f298e202
work_keys_str_mv	AT banj cornealpermeationpropertiesofachargedlipidnanoparticlecarriercontainingdexamethasone AT zhangy cornealpermeationpropertiesofachargedlipidnanoparticlecarriercontainingdexamethasone AT huangx cornealpermeationpropertiesofachargedlipidnanoparticlecarriercontainingdexamethasone AT denggh cornealpermeationpropertiesofachargedlipidnanoparticlecarriercontainingdexamethasone AT houdz cornealpermeationpropertiesofachargedlipidnanoparticlecarriercontainingdexamethasone AT chenyz cornealpermeationpropertiesofachargedlipidnanoparticlecarriercontainingdexamethasone AT luzf cornealpermeationpropertiesofachargedlipidnanoparticlecarriercontainingdexamethasone
_version_	1718401506914336768

Corneal permeation properties of a charged lipid nanoparticle carrier containing dexamethasone

Ejemplares similares