The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.

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Autores principales:	Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/96fad901a4ef46c28beb417658674b86
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spelling	oai:doaj.org-article:96fad901a4ef46c28beb417658674b862021-12-02T15:35:00ZThe Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization10.1038/ncomms135172041-1723https://doaj.org/article/96fad901a4ef46c28beb417658674b862016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13517https://doaj.org/toc/2041-1723Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.Feng ZhangClaudia PrahstThomas MathivetLaurence Pibouin-FragnerJiasheng ZhangGael GenetRaymond TongAlexandre DubracAnne EichmannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Zhang Claudia Prahst Thomas Mathivet Laurence Pibouin-Fragner Jiasheng Zhang Gael Genet Raymond Tong Alexandre Dubrac Anne Eichmann The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
description	Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosphorylation of its receptor Vegfr2 on Y949.
format	article
author	Feng Zhang Claudia Prahst Thomas Mathivet Laurence Pibouin-Fragner Jiasheng Zhang Gael Genet Raymond Tong Alexandre Dubrac Anne Eichmann
author_facet	Feng Zhang Claudia Prahst Thomas Mathivet Laurence Pibouin-Fragner Jiasheng Zhang Gael Genet Raymond Tong Alexandre Dubrac Anne Eichmann
author_sort	Feng Zhang
title	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_short	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_full	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_fullStr	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_full_unstemmed	The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
title_sort	robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/96fad901a4ef46c28beb417658674b86
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The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

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