Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China

Campylobacter jejuni (C. jejuni) is the leading causative agent of gastroenteritis and Guillain–Barré syndrome (GBS). Capsular polysaccharide (CPS) and lipooligosaccharide (LOS) contribute to the susceptibility of campylobacteriosis, which have been concern the major evaluation indicators of C. jeju...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaoqi Zang, Hongyue Lv, Haiyan Tang, Xinan Jiao, Jinlin Huang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Campylobacter jejuni capsular genotype lipooligosaccharide class multilocus sequence typing enteritis and Guillain–Barré syndrome isolates from food animal Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/96fe58a01e1a4e54b43ffacbf64d2d00
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:96fe58a01e1a4e54b43ffacbf64d2d00
record_format	dspace
spelling	oai:doaj.org-article:96fe58a01e1a4e54b43ffacbf64d2d002021-11-22T06:24:15ZCapsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China1664-302X10.3389/fmicb.2021.775090https://doaj.org/article/96fe58a01e1a4e54b43ffacbf64d2d002021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.775090/fullhttps://doaj.org/toc/1664-302XCampylobacter jejuni (C. jejuni) is the leading causative agent of gastroenteritis and Guillain–Barré syndrome (GBS). Capsular polysaccharide (CPS) and lipooligosaccharide (LOS) contribute to the susceptibility of campylobacteriosis, which have been concern the major evaluation indicators of C. jejuni isolates from clinical patients. As a foodborne disease, food animal plays a primary role in the infection of campylobacteriosis. To assess the pathogenic characterizations of C. jejuni isolates from various ecological origins, 1609 isolates sampled from 2005 to 2019 in China were analyzed using capsular genotyping. Strains from cattle and poultry were further characterized by LOS classification and multilocus sequence typing (MLST), compared with the isolates from human patients worldwide with enteritis and GBS. Results showed that the disease associated capsular genotypes and LOS classes over-represented in human isolates were also dominant in animal isolates, especially cattle isolates. Based on the same disease associated capsular genotype, more LOS class types were represented by food animal isolates than human disease isolates. Importantly, high-risk lineages CC-22, CC-464, and CC-21 were found dominated in human isolates with GBS worldwide, which were also represented in the food animal isolates with disease associated capsular types, suggesting a possibility of clonal spread of isolates across different regions and hosts. This is the first study providing genetic evidence for food animal isolates of particular capsular genotypes harbor similar pathogenic characteristics to human clinical isolates. Collective efforts for campylobacteriosis hazard control need to be focused on the zoonotic pathogenicity of animal isolates, along the food chain “from farm to table.”Xiaoqi ZangHongyue LvHaiyan TangXinan JiaoJinlin HuangJinlin HuangJinlin HuangFrontiers Media S.A.articleCampylobacter jejunicapsular genotypelipooligosaccharide classmultilocus sequence typingenteritis and Guillain–Barré syndromeisolates from food animalMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Campylobacter jejuni capsular genotype lipooligosaccharide class multilocus sequence typing enteritis and Guillain–Barré syndrome isolates from food animal Microbiology QR1-502
spellingShingle	Campylobacter jejuni capsular genotype lipooligosaccharide class multilocus sequence typing enteritis and Guillain–Barré syndrome isolates from food animal Microbiology QR1-502 Xiaoqi Zang Hongyue Lv Haiyan Tang Xinan Jiao Jinlin Huang Jinlin Huang Jinlin Huang Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China
description	Campylobacter jejuni (C. jejuni) is the leading causative agent of gastroenteritis and Guillain–Barré syndrome (GBS). Capsular polysaccharide (CPS) and lipooligosaccharide (LOS) contribute to the susceptibility of campylobacteriosis, which have been concern the major evaluation indicators of C. jejuni isolates from clinical patients. As a foodborne disease, food animal plays a primary role in the infection of campylobacteriosis. To assess the pathogenic characterizations of C. jejuni isolates from various ecological origins, 1609 isolates sampled from 2005 to 2019 in China were analyzed using capsular genotyping. Strains from cattle and poultry were further characterized by LOS classification and multilocus sequence typing (MLST), compared with the isolates from human patients worldwide with enteritis and GBS. Results showed that the disease associated capsular genotypes and LOS classes over-represented in human isolates were also dominant in animal isolates, especially cattle isolates. Based on the same disease associated capsular genotype, more LOS class types were represented by food animal isolates than human disease isolates. Importantly, high-risk lineages CC-22, CC-464, and CC-21 were found dominated in human isolates with GBS worldwide, which were also represented in the food animal isolates with disease associated capsular types, suggesting a possibility of clonal spread of isolates across different regions and hosts. This is the first study providing genetic evidence for food animal isolates of particular capsular genotypes harbor similar pathogenic characteristics to human clinical isolates. Collective efforts for campylobacteriosis hazard control need to be focused on the zoonotic pathogenicity of animal isolates, along the food chain “from farm to table.”
format	article
author	Xiaoqi Zang Hongyue Lv Haiyan Tang Xinan Jiao Jinlin Huang Jinlin Huang Jinlin Huang
author_facet	Xiaoqi Zang Hongyue Lv Haiyan Tang Xinan Jiao Jinlin Huang Jinlin Huang Jinlin Huang
author_sort	Xiaoqi Zang
title	Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China
title_short	Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China
title_full	Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China
title_fullStr	Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China
title_full_unstemmed	Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China
title_sort	capsular genotype and lipooligosaccharide class associated genomic characterizations of campylobacter jejuni isolates from food animals in china
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/96fe58a01e1a4e54b43ffacbf64d2d00
work_keys_str_mv	AT xiaoqizang capsulargenotypeandlipooligosaccharideclassassociatedgenomiccharacterizationsofcampylobacterjejuniisolatesfromfoodanimalsinchina AT hongyuelv capsulargenotypeandlipooligosaccharideclassassociatedgenomiccharacterizationsofcampylobacterjejuniisolatesfromfoodanimalsinchina AT haiyantang capsulargenotypeandlipooligosaccharideclassassociatedgenomiccharacterizationsofcampylobacterjejuniisolatesfromfoodanimalsinchina AT xinanjiao capsulargenotypeandlipooligosaccharideclassassociatedgenomiccharacterizationsofcampylobacterjejuniisolatesfromfoodanimalsinchina AT jinlinhuang capsulargenotypeandlipooligosaccharideclassassociatedgenomiccharacterizationsofcampylobacterjejuniisolatesfromfoodanimalsinchina AT jinlinhuang capsulargenotypeandlipooligosaccharideclassassociatedgenomiccharacterizationsofcampylobacterjejuniisolatesfromfoodanimalsinchina AT jinlinhuang capsulargenotypeandlipooligosaccharideclassassociatedgenomiccharacterizationsofcampylobacterjejuniisolatesfromfoodanimalsinchina
_version_	1718418116774461440

Capsular Genotype and Lipooligosaccharide Class Associated Genomic Characterizations of Campylobacter jejuni Isolates From Food Animals in China

Ejemplares similares