Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation

Abstract Atrial remodeling with fibrosis has been well-described in patients with atrial fibrillation (AF). We hypothesized that the left atrial (LA)-late gadolinium enhancement (LGE) extent on cardiac magnetic resonance (CMR) imaging is associated with LA pressure and can be a marker for suitable c...

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Autores principales:	Seung-Young Roh, Dae In Lee, Sung Ho Hwang, Kwang-No Lee, Yong-soo Baek, Mohammad Iqbal, Dong-Hyeok Kim, Jinhee Ahn, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/96fe9a359d954dbc9b81ad2a81b53ff8
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spelling	oai:doaj.org-article:96fe9a359d954dbc9b81ad2a81b53ff82021-12-02T18:36:13ZAssociation of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation10.1038/s41598-020-72929-02045-2322https://doaj.org/article/96fe9a359d954dbc9b81ad2a81b53ff82020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72929-0https://doaj.org/toc/2045-2322Abstract Atrial remodeling with fibrosis has been well-described in patients with atrial fibrillation (AF). We hypothesized that the left atrial (LA)-late gadolinium enhancement (LGE) extent on cardiac magnetic resonance (CMR) imaging is associated with LA pressure and can be a marker for suitable candidates for non-paroxysmal AF ablation. A total of 173 AF patients with an LA-LGE area on CMR imaging were enrolled. The clinical parameters, including invasively measured LA pressure, were compared between the patients with extensive LA-LGE (E-LGE, LGE extent ≥ 20%, n = 78) and those with small LA-LGE (S-LGE, LGE extent < 20%, n = 95). The E-LGE group had higher peak LA pressures than the S-LGE group (23 versus 19 mmHg, p < 0.001). The E-LGE group had more patients with non-paroxysmal AF (non-PAF) (51% vs. 34%), heart failure (9% vs. 0%), and higher NT pro-B-type natriuretic peptide (472 vs. 265 pg/ml) (all p < 0.05). LA pressure ≥ 21 mmHg was an independent predictor of E-LGE (OR = 2.218; p = 0.019). In the paroxysmal AF (PAF) subgroup, freedom from atrial arrhythmia after catheter ablation was not different (81% vs 86%, log-rank p = 0.529). However, in the non-PAF subgroup, it was significantly higher in the S-LGE group than in the E-LGE group (81% vs 55%, log-rank p = 0.014). Increased LA pressure was related to the LA-LGE extent. LA-LGE was a good predictor of outcome after catheter ablation, but only in patients with non-PAF.Seung-Young RohDae In LeeSung Ho HwangKwang-No LeeYong-soo BaekMohammad IqbalDong-Hyeok KimJinhee AhnJaemin ShimJong-Il ChoiYoung-Hoon KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seung-Young Roh Dae In Lee Sung Ho Hwang Kwang-No Lee Yong-soo Baek Mohammad Iqbal Dong-Hyeok Kim Jinhee Ahn Jaemin Shim Jong-Il Choi Young-Hoon Kim Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation
description	Abstract Atrial remodeling with fibrosis has been well-described in patients with atrial fibrillation (AF). We hypothesized that the left atrial (LA)-late gadolinium enhancement (LGE) extent on cardiac magnetic resonance (CMR) imaging is associated with LA pressure and can be a marker for suitable candidates for non-paroxysmal AF ablation. A total of 173 AF patients with an LA-LGE area on CMR imaging were enrolled. The clinical parameters, including invasively measured LA pressure, were compared between the patients with extensive LA-LGE (E-LGE, LGE extent ≥ 20%, n = 78) and those with small LA-LGE (S-LGE, LGE extent < 20%, n = 95). The E-LGE group had higher peak LA pressures than the S-LGE group (23 versus 19 mmHg, p < 0.001). The E-LGE group had more patients with non-paroxysmal AF (non-PAF) (51% vs. 34%), heart failure (9% vs. 0%), and higher NT pro-B-type natriuretic peptide (472 vs. 265 pg/ml) (all p < 0.05). LA pressure ≥ 21 mmHg was an independent predictor of E-LGE (OR = 2.218; p = 0.019). In the paroxysmal AF (PAF) subgroup, freedom from atrial arrhythmia after catheter ablation was not different (81% vs 86%, log-rank p = 0.529). However, in the non-PAF subgroup, it was significantly higher in the S-LGE group than in the E-LGE group (81% vs 55%, log-rank p = 0.014). Increased LA pressure was related to the LA-LGE extent. LA-LGE was a good predictor of outcome after catheter ablation, but only in patients with non-PAF.
format	article
author	Seung-Young Roh Dae In Lee Sung Ho Hwang Kwang-No Lee Yong-soo Baek Mohammad Iqbal Dong-Hyeok Kim Jinhee Ahn Jaemin Shim Jong-Il Choi Young-Hoon Kim
author_facet	Seung-Young Roh Dae In Lee Sung Ho Hwang Kwang-No Lee Yong-soo Baek Mohammad Iqbal Dong-Hyeok Kim Jinhee Ahn Jaemin Shim Jong-Il Choi Young-Hoon Kim
author_sort	Seung-Young Roh
title	Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation
title_short	Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation
title_full	Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation
title_fullStr	Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation
title_full_unstemmed	Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation
title_sort	association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/96fe9a359d954dbc9b81ad2a81b53ff8
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Association of left atrial pressure with late gadolinium enhancement extent in patient who underwent catheter ablation for atrial fibrillation

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