Supramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation

Chitosan-based intelligent artificial systems have been of increasing interest for their biocompatibility, multifunctionality, biological activity, and low cost. Herein, we report the fabrication of supramolecular nanoparticles based on water-soluble chitosan (WCS) and 1,1′,1″,1″′-(ethene-1,1,2,2-te...

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Autores principales:	An Liu, Hong Song, Puyou Jia, Ying Lin, Qingping Song, Jiangang Gao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi-Wiley 2021
Materias:	Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/96febecd672e4497befe4bc6f5c34a9a
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spelling	oai:doaj.org-article:96febecd672e4497befe4bc6f5c34a9a2021-11-22T01:09:44ZSupramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation1098-232910.1155/2021/5175473https://doaj.org/article/96febecd672e4497befe4bc6f5c34a9a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5175473https://doaj.org/toc/1098-2329Chitosan-based intelligent artificial systems have been of increasing interest for their biocompatibility, multifunctionality, biological activity, and low cost. Herein, we report the fabrication of supramolecular nanoparticles based on water-soluble chitosan (WCS) and 1,1′,1″,1″′-(ethene-1,1,2,2-tetrayl)tetrakis(benzene-4,1-diyl) tetrakis(azanediyl)tetraacetic acid (TPE-(N-COOH)4), which is capable of reversible transition between polyion complexes (PICs) and hydrogen bonding complexes (HBCs) with tunable aggregation-induced emission driven by pH value. The PIC micelles could be formed via electrostatic interaction between ammonium cations and carboxylate anions under mild alkaline conditions. The formation of the micelles dramatically blocks the nonradiative pathway and enhances the fluorescence of TPE moieties, and the maximum fluorescence intensity was achieved near the isoelectric point due to the restriction of intramolecular motion. In addition, the fluorescence intensity and size of the PIC micelles exhibited a temperature response in the range from 20 to 80°C. Upon adjusting the solution pH to 2, the PIC micelles were reconstructed into hydrogen-bonding complexes while the hydrogen bonding interaction between the protonated carboxyl groups of TPE-(N-COOH)4 and chitosan. Moreover, the size of the micelles underwent a remarkable decrease, whereas the fluorescence emission was further enhanced by ~6.25-fold. The pH actuated micellar transition from PIC to HBC with tunable fluorescence performance is fully reversible. This study provides novel multifunctional materials that are of great importance for their potential application in the fields of optoelectronic devices and chemical and biomedical sensors.An LiuHong SongPuyou JiaYing LinQingping SongJiangang GaoHindawi-WileyarticlePolymers and polymer manufactureTP1080-1185ENAdvances in Polymer Technology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polymers and polymer manufacture TP1080-1185
spellingShingle	Polymers and polymer manufacture TP1080-1185 An Liu Hong Song Puyou Jia Ying Lin Qingping Song Jiangang Gao Supramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation
description	Chitosan-based intelligent artificial systems have been of increasing interest for their biocompatibility, multifunctionality, biological activity, and low cost. Herein, we report the fabrication of supramolecular nanoparticles based on water-soluble chitosan (WCS) and 1,1′,1″,1″′-(ethene-1,1,2,2-tetrayl)tetrakis(benzene-4,1-diyl) tetrakis(azanediyl)tetraacetic acid (TPE-(N-COOH)4), which is capable of reversible transition between polyion complexes (PICs) and hydrogen bonding complexes (HBCs) with tunable aggregation-induced emission driven by pH value. The PIC micelles could be formed via electrostatic interaction between ammonium cations and carboxylate anions under mild alkaline conditions. The formation of the micelles dramatically blocks the nonradiative pathway and enhances the fluorescence of TPE moieties, and the maximum fluorescence intensity was achieved near the isoelectric point due to the restriction of intramolecular motion. In addition, the fluorescence intensity and size of the PIC micelles exhibited a temperature response in the range from 20 to 80°C. Upon adjusting the solution pH to 2, the PIC micelles were reconstructed into hydrogen-bonding complexes while the hydrogen bonding interaction between the protonated carboxyl groups of TPE-(N-COOH)4 and chitosan. Moreover, the size of the micelles underwent a remarkable decrease, whereas the fluorescence emission was further enhanced by ~6.25-fold. The pH actuated micellar transition from PIC to HBC with tunable fluorescence performance is fully reversible. This study provides novel multifunctional materials that are of great importance for their potential application in the fields of optoelectronic devices and chemical and biomedical sensors.
format	article
author	An Liu Hong Song Puyou Jia Ying Lin Qingping Song Jiangang Gao
author_facet	An Liu Hong Song Puyou Jia Ying Lin Qingping Song Jiangang Gao
author_sort	An Liu
title	Supramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation
title_short	Supramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation
title_full	Supramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation
title_fullStr	Supramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation
title_full_unstemmed	Supramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation
title_sort	supramolecular assembly and reversible transition and of chitosan fluorescent micelles by noncovalent modulation
publisher	Hindawi-Wiley
publishDate	2021
url	https://doaj.org/article/96febecd672e4497befe4bc6f5c34a9a
work_keys_str_mv	AT anliu supramolecularassemblyandreversibletransitionandofchitosanfluorescentmicellesbynoncovalentmodulation AT hongsong supramolecularassemblyandreversibletransitionandofchitosanfluorescentmicellesbynoncovalentmodulation AT puyoujia supramolecularassemblyandreversibletransitionandofchitosanfluorescentmicellesbynoncovalentmodulation AT yinglin supramolecularassemblyandreversibletransitionandofchitosanfluorescentmicellesbynoncovalentmodulation AT qingpingsong supramolecularassemblyandreversibletransitionandofchitosanfluorescentmicellesbynoncovalentmodulation AT jianganggao supramolecularassemblyandreversibletransitionandofchitosanfluorescentmicellesbynoncovalentmodulation
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Supramolecular Assembly and Reversible Transition and of Chitosan Fluorescent Micelles by Noncovalent Modulation

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