How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?

COVID-19 patients suffering from severe acute respiratory distress syndrome (ARDS) require mechanical ventilation (MV) for respiratory failure. To achieve these ventilatory goals, it has been observed that COVID-19 patients in particular require high regimens and prolonged use of sedatives, analgesi...

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Autores principales:	Amédée Ego, Katarina Halenarova, Jacques Creteur, Fabio Silvio Taccone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sedation analgesia COVID-19 withdrawal management Medicine R
Acceso en línea:	https://doaj.org/article/96ff6a5cc4a542e09364edc608b6cece
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spelling	oai:doaj.org-article:96ff6a5cc4a542e09364edc608b6cece2021-11-11T17:33:31ZHow to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?10.3390/jcm102149172077-0383https://doaj.org/article/96ff6a5cc4a542e09364edc608b6cece2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4917https://doaj.org/toc/2077-0383COVID-19 patients suffering from severe acute respiratory distress syndrome (ARDS) require mechanical ventilation (MV) for respiratory failure. To achieve these ventilatory goals, it has been observed that COVID-19 patients in particular require high regimens and prolonged use of sedatives, analgesics and neuromuscular blocking agents (NMBA). Withdrawal from analgo-sedation may induce a “drug withdrawal syndrome” (DWS), i.e., clinical symptoms of anxiety, tremor, agitation, hallucinations and vomiting, as a result of adrenergic activation and hyperalgesia. We describe the epidemiology, mechanisms leading to this syndrome and our strategies to prevent and treat it.Amédée EgoKatarina HalenarovaJacques CreteurFabio Silvio TacconeMDPI AGarticlesedationanalgesiaCOVID-19withdrawalmanagementMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4917, p 4917 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sedation analgesia COVID-19 withdrawal management Medicine R
spellingShingle	sedation analgesia COVID-19 withdrawal management Medicine R Amédée Ego Katarina Halenarova Jacques Creteur Fabio Silvio Taccone How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?
description	COVID-19 patients suffering from severe acute respiratory distress syndrome (ARDS) require mechanical ventilation (MV) for respiratory failure. To achieve these ventilatory goals, it has been observed that COVID-19 patients in particular require high regimens and prolonged use of sedatives, analgesics and neuromuscular blocking agents (NMBA). Withdrawal from analgo-sedation may induce a “drug withdrawal syndrome” (DWS), i.e., clinical symptoms of anxiety, tremor, agitation, hallucinations and vomiting, as a result of adrenergic activation and hyperalgesia. We describe the epidemiology, mechanisms leading to this syndrome and our strategies to prevent and treat it.
format	article
author	Amédée Ego Katarina Halenarova Jacques Creteur Fabio Silvio Taccone
author_facet	Amédée Ego Katarina Halenarova Jacques Creteur Fabio Silvio Taccone
author_sort	Amédée Ego
title	How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?
title_short	How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?
title_full	How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?
title_fullStr	How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?
title_full_unstemmed	How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?
title_sort	how to manage withdrawal of sedation and analgesia in mechanically ventilated covid-19 patients?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/96ff6a5cc4a542e09364edc608b6cece
work_keys_str_mv	AT amedeeego howtomanagewithdrawalofsedationandanalgesiainmechanicallyventilatedcovid19patients AT katarinahalenarova howtomanagewithdrawalofsedationandanalgesiainmechanicallyventilatedcovid19patients AT jacquescreteur howtomanagewithdrawalofsedationandanalgesiainmechanicallyventilatedcovid19patients AT fabiosilviotaccone howtomanagewithdrawalofsedationandanalgesiainmechanicallyventilatedcovid19patients
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How to Manage Withdrawal of Sedation and Analgesia in Mechanically Ventilated COVID-19 Patients?

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