Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

Laminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diab...

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Autores principales:	Jun Ishihara, Ako Ishihara, Kazuto Fukunaga, Koichi Sasaki, Michael J. V. White, Priscilla S. Briquez, Jeffrey A. Hubbell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/970479756e7a4accbe4500ad2b9305a7
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spelling	oai:doaj.org-article:970479756e7a4accbe4500ad2b9305a72021-12-02T15:33:41ZLaminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing10.1038/s41467-018-04525-w2041-1723https://doaj.org/article/970479756e7a4accbe4500ad2b9305a72018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04525-whttps://doaj.org/toc/2041-1723Laminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diabetic mouse models.Jun IshiharaAko IshiharaKazuto FukunagaKoichi SasakiMichael J. V. WhitePriscilla S. BriquezJeffrey A. HubbellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Ishihara Ako Ishihara Kazuto Fukunaga Koichi Sasaki Michael J. V. White Priscilla S. Briquez Jeffrey A. Hubbell Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
description	Laminins are important regulators of epidermal wound healing. Here, the authors show that laminins bind to multiple growth factors via their heparin-binding domains, and that incorporation of these domains into fibrin matrices increases growth factor retention, promoting wound healing in type 2 diabetic mouse models.
format	article
author	Jun Ishihara Ako Ishihara Kazuto Fukunaga Koichi Sasaki Michael J. V. White Priscilla S. Briquez Jeffrey A. Hubbell
author_facet	Jun Ishihara Ako Ishihara Kazuto Fukunaga Koichi Sasaki Michael J. V. White Priscilla S. Briquez Jeffrey A. Hubbell
author_sort	Jun Ishihara
title	Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
title_short	Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
title_full	Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
title_fullStr	Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
title_full_unstemmed	Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
title_sort	laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/970479756e7a4accbe4500ad2b9305a7
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Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

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