The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury

Diazinon, one of the most known organophosphate pesticides (OPs), has harmful effects on human organs. Acetylcholinesterase inhibition, oxidative stress, and inflammation are the major mechanisms of diazinon toxicity. Diazinon has several toxic effects on the liver. Resveratrol (RES) is a natural po...

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Autores principales:	Fereshteh Mehri, Mohammad Taghi Goodarzi, Maryam Esfahani
Formato:	article
Lenguaje:	EN
Publicado:	Hamadan University of Medical Sciences 2020
Materias:	diazinon oxidative stress inflammation liver toxicity resveratrol Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/97056e9f27f846258f0b28250583f9de
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spelling	oai:doaj.org-article:97056e9f27f846258f0b28250583f9de2021-11-20T09:27:37ZThe Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury10.34172/ajmb.2020.062345-4113https://doaj.org/article/97056e9f27f846258f0b28250583f9de2020-06-01T00:00:00Zhttp://ajmb.umsha.ac.ir/PDF/ajmb-8-44.pdfhttps://doaj.org/toc/2345-4113Diazinon, one of the most known organophosphate pesticides (OPs), has harmful effects on human organs. Acetylcholinesterase inhibition, oxidative stress, and inflammation are the major mechanisms of diazinon toxicity. Diazinon has several toxic effects on the liver. Resveratrol (RES) is a natural polyphenol compound with antitumor, anti-diabetic, anti-obesity, anti-oxidant, anti-aging, and anti-inflammatory effects. This compound can inhibit lipid peroxidation, protein oxidation, and DNA damage. Moreover, it can induce sirt-1, PI3K/AKT, and HO-1 pathways (negative regulators of inflammatory pathways). A large body of evidence indicated that resveratrol can attenuate liver damage by organophosphates. In this short review, we discuss the significant role of this phytoestrogen and antioxidant against the hepatotoxic effect of diazinon as an OP. With elucidation of the role of this supplement in reducing harmful effects of diazinon, it can be used as a protective agent in people at risk of adverse effects of diazinon. Fereshteh MehriMohammad Taghi GoodarziMaryam Esfahani Hamadan University of Medical Sciencesarticlediazinonoxidative stressinflammationlivertoxicityresveratrolMedical technologyR855-855.5ENAvicenna Journal of Medical Biochemistry, Vol 8, Iss 1, Pp 44-48 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diazinon oxidative stress inflammation liver toxicity resveratrol Medical technology R855-855.5
spellingShingle	diazinon oxidative stress inflammation liver toxicity resveratrol Medical technology R855-855.5 Fereshteh Mehri Mohammad Taghi Goodarzi Maryam Esfahani The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury
description	Diazinon, one of the most known organophosphate pesticides (OPs), has harmful effects on human organs. Acetylcholinesterase inhibition, oxidative stress, and inflammation are the major mechanisms of diazinon toxicity. Diazinon has several toxic effects on the liver. Resveratrol (RES) is a natural polyphenol compound with antitumor, anti-diabetic, anti-obesity, anti-oxidant, anti-aging, and anti-inflammatory effects. This compound can inhibit lipid peroxidation, protein oxidation, and DNA damage. Moreover, it can induce sirt-1, PI3K/AKT, and HO-1 pathways (negative regulators of inflammatory pathways). A large body of evidence indicated that resveratrol can attenuate liver damage by organophosphates. In this short review, we discuss the significant role of this phytoestrogen and antioxidant against the hepatotoxic effect of diazinon as an OP. With elucidation of the role of this supplement in reducing harmful effects of diazinon, it can be used as a protective agent in people at risk of adverse effects of diazinon.
format	article
author	Fereshteh Mehri Mohammad Taghi Goodarzi Maryam Esfahani
author_facet	Fereshteh Mehri Mohammad Taghi Goodarzi Maryam Esfahani
author_sort	Fereshteh Mehri
title	The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury
title_short	The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury
title_full	The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury
title_fullStr	The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury
title_full_unstemmed	The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury
title_sort	possible protective effect of resveratrol on diazinoninduced oxidative stress and hepatic injury
publisher	Hamadan University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/97056e9f27f846258f0b28250583f9de
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The Possible Protective Effect of Resveratrol on DiazinonInduced Oxidative Stress and Hepatic Injury

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