Changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines

The microbiological profile, associated risk factors and demographic characteristics of patients with IE has changed in the recent times. In the present study, the antibiotic susceptibility profile of 66 isolates (40 from IDU and 26 from non IDU) recovered over a period of three years from the patie...

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Autores principales:	Rama Gupta, Vandana Kaushal, Abhishek Goyal, Pawan Kumar, Dinesh Gupta, Rohit Tandon, Aashita Mahajan, Sonaal Singla, Gurbhej Singh, Bhupinder Singh, Shibba Takkar Chhabra, Naved Aslam, Gurpreet S. Wander, Veenu Gupta, Bishav Mohan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Infective endocarditis Microbiological profile Minimum inhibitory concentrations Guidelines Intravenous drug users Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/9707ec391e99437ea8e9ba9ef0d73683
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spelling	oai:doaj.org-article:9707ec391e99437ea8e9ba9ef0d736832021-12-02T04:58:04ZChanging microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines0019-483210.1016/j.ihj.2021.10.013https://doaj.org/article/9707ec391e99437ea8e9ba9ef0d736832021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0019483221002327https://doaj.org/toc/0019-4832The microbiological profile, associated risk factors and demographic characteristics of patients with IE has changed in the recent times. In the present study, the antibiotic susceptibility profile of 66 isolates (40 from IDU and 26 from non IDU) recovered over a period of three years from the patients with definitive diagnosis of IE along with their absolute minimum inhibitory concentrations (MIC-μg/ml) was determined as per CLSI, 2017 guidelines. Staphylococcus aureus was found to be the predominant pathogen associated with IE out of which 90.2% isolates were MRSA, although none of the isolates were found resistant to vancomycin, teicoplanin, daptomycin and linezolid. Pseudomonas aeruginosa isolates were 100% susceptible to carbapenams, however variable resistance was observed against other antimicrobials. All Enterococci were found to be 100% susceptible to linezolid and daptomycin, whereas vancomycin resistant enterococci phenotype was observed in 25% of the Enterococcal isolates. A noticeable difference in the antimicrobial susceptibility profile and their MICs were observed in the present study, as compared to published literature across the globe and within the country. However, no statistically significant difference (λ 2 test, p > 0.01)in the AST pattern of isolates from IDU vs. Non IDU was observed. After reviewing the local antibiogram it seems that we need to have our own regional guidelines, which may partially replace the currently prevailing AHA/ESC guidelines.Rama GuptaVandana KaushalAbhishek GoyalPawan KumarDinesh GuptaRohit TandonAashita MahajanSonaal SinglaGurbhej SinghBhupinder SinghShibba Takkar ChhabraNaved AslamGurpreet S. WanderVeenu GuptaBishav MohanElsevierarticleInfective endocarditisMicrobiological profileMinimum inhibitory concentrationsGuidelinesIntravenous drug usersSurgeryRD1-811Diseases of the circulatory (Cardiovascular) systemRC666-701ENIndian Heart Journal, Vol 73, Iss 6, Pp 704-710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infective endocarditis Microbiological profile Minimum inhibitory concentrations Guidelines Intravenous drug users Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Infective endocarditis Microbiological profile Minimum inhibitory concentrations Guidelines Intravenous drug users Surgery RD1-811 Diseases of the circulatory (Cardiovascular) system RC666-701 Rama Gupta Vandana Kaushal Abhishek Goyal Pawan Kumar Dinesh Gupta Rohit Tandon Aashita Mahajan Sonaal Singla Gurbhej Singh Bhupinder Singh Shibba Takkar Chhabra Naved Aslam Gurpreet S. Wander Veenu Gupta Bishav Mohan Changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines
description	The microbiological profile, associated risk factors and demographic characteristics of patients with IE has changed in the recent times. In the present study, the antibiotic susceptibility profile of 66 isolates (40 from IDU and 26 from non IDU) recovered over a period of three years from the patients with definitive diagnosis of IE along with their absolute minimum inhibitory concentrations (MIC-μg/ml) was determined as per CLSI, 2017 guidelines. Staphylococcus aureus was found to be the predominant pathogen associated with IE out of which 90.2% isolates were MRSA, although none of the isolates were found resistant to vancomycin, teicoplanin, daptomycin and linezolid. Pseudomonas aeruginosa isolates were 100% susceptible to carbapenams, however variable resistance was observed against other antimicrobials. All Enterococci were found to be 100% susceptible to linezolid and daptomycin, whereas vancomycin resistant enterococci phenotype was observed in 25% of the Enterococcal isolates. A noticeable difference in the antimicrobial susceptibility profile and their MICs were observed in the present study, as compared to published literature across the globe and within the country. However, no statistically significant difference (λ 2 test, p > 0.01)in the AST pattern of isolates from IDU vs. Non IDU was observed. After reviewing the local antibiogram it seems that we need to have our own regional guidelines, which may partially replace the currently prevailing AHA/ESC guidelines.
format	article
author	Rama Gupta Vandana Kaushal Abhishek Goyal Pawan Kumar Dinesh Gupta Rohit Tandon Aashita Mahajan Sonaal Singla Gurbhej Singh Bhupinder Singh Shibba Takkar Chhabra Naved Aslam Gurpreet S. Wander Veenu Gupta Bishav Mohan
author_facet	Rama Gupta Vandana Kaushal Abhishek Goyal Pawan Kumar Dinesh Gupta Rohit Tandon Aashita Mahajan Sonaal Singla Gurbhej Singh Bhupinder Singh Shibba Takkar Chhabra Naved Aslam Gurpreet S. Wander Veenu Gupta Bishav Mohan
author_sort	Rama Gupta
title	Changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines
title_short	Changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines
title_full	Changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines
title_fullStr	Changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines
title_full_unstemmed	Changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines
title_sort	changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – the time to relook into the therapeutic guidelines
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9707ec391e99437ea8e9ba9ef0d73683
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Changing microbiological profile and antimicrobial susceptibility of the isolates obtained from patients with infective endocarditis – The time to relook into the therapeutic guidelines

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