Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes

Abstract Polycystic ovary syndrome (PCOS) is a common problem among Arab women and is the main cause of infertility due to anovulation. This study investigates insulin resistance (IR) and obesity in different PCOS phenotypes among infertile women (n = 213), of whom 159 had PCOS and 54 women without...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Moamar Al-Jefout, Nedal Alnawaiseh, Aiman Al-Qtaitat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/970c5fc9cc9b47d0bdf31186b6e8d109
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:970c5fc9cc9b47d0bdf31186b6e8d109
record_format	dspace
spelling	oai:doaj.org-article:970c5fc9cc9b47d0bdf31186b6e8d1092021-12-02T12:32:46ZInsulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes10.1038/s41598-017-05717-y2045-2322https://doaj.org/article/970c5fc9cc9b47d0bdf31186b6e8d1092017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05717-yhttps://doaj.org/toc/2045-2322Abstract Polycystic ovary syndrome (PCOS) is a common problem among Arab women and is the main cause of infertility due to anovulation. This study investigates insulin resistance (IR) and obesity in different PCOS phenotypes among infertile women (n = 213), of whom 159 had PCOS and 54 women without PCOS, recruited as a control group. Biometric, hormonal and clinical parameters were studied. IR was observed in 133 (83.6%) women with PCOS and in 25 (46.3%) women without PCOS (p < 0.001). IR was significantly associated with PCOS only among women with central obesity (χ2 = 35.0, p < 0.001) and not for the normal category (χ2 = 4.04, p < 0.058). The LH/FSH ratio was not significantly different among the PCOS group (n = 37, 23.3%) compared to the control group (n = 9, 16.7%) (p = 0.308). Among women with PCOS, the most common phenotype was type I (50.3%), with type III (29.6%), type II (14.5%) and type IV (5.7%). Type I had the highest values of fasting insulin (median = 12.98 mU/mL) and HOMA IR values (significant difference among the four phenotypes, p = 0.009 and 0.006, respectively) and is associated with severity of the disease. There was no difference in glucose levels.Moamar Al-JefoutNedal AlnawaisehAiman Al-QtaitatNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moamar Al-Jefout Nedal Alnawaiseh Aiman Al-Qtaitat Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
description	Abstract Polycystic ovary syndrome (PCOS) is a common problem among Arab women and is the main cause of infertility due to anovulation. This study investigates insulin resistance (IR) and obesity in different PCOS phenotypes among infertile women (n = 213), of whom 159 had PCOS and 54 women without PCOS, recruited as a control group. Biometric, hormonal and clinical parameters were studied. IR was observed in 133 (83.6%) women with PCOS and in 25 (46.3%) women without PCOS (p < 0.001). IR was significantly associated with PCOS only among women with central obesity (χ2 = 35.0, p < 0.001) and not for the normal category (χ2 = 4.04, p < 0.058). The LH/FSH ratio was not significantly different among the PCOS group (n = 37, 23.3%) compared to the control group (n = 9, 16.7%) (p = 0.308). Among women with PCOS, the most common phenotype was type I (50.3%), with type III (29.6%), type II (14.5%) and type IV (5.7%). Type I had the highest values of fasting insulin (median = 12.98 mU/mL) and HOMA IR values (significant difference among the four phenotypes, p = 0.009 and 0.006, respectively) and is associated with severity of the disease. There was no difference in glucose levels.
format	article
author	Moamar Al-Jefout Nedal Alnawaiseh Aiman Al-Qtaitat
author_facet	Moamar Al-Jefout Nedal Alnawaiseh Aiman Al-Qtaitat
author_sort	Moamar Al-Jefout
title	Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_short	Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_full	Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_fullStr	Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_full_unstemmed	Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
title_sort	insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/970c5fc9cc9b47d0bdf31186b6e8d109
work_keys_str_mv	AT moamaraljefout insulinresistanceandobesityamonginfertilewomenwithdifferentpolycysticovarysyndromephenotypes AT nedalalnawaiseh insulinresistanceandobesityamonginfertilewomenwithdifferentpolycysticovarysyndromephenotypes AT aimanalqtaitat insulinresistanceandobesityamonginfertilewomenwithdifferentpolycysticovarysyndromephenotypes
_version_	1718393993311551488

Insulin resistance and obesity among infertile women with different polycystic ovary syndrome phenotypes

Ejemplares similares