2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.
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Nature Portfolio
2020
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oai:doaj.org-article:970f33637b174d7ca2db00d47c85ff082021-12-02T15:39:20Z2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations10.1038/s41467-020-15140-z2041-1723https://doaj.org/article/970f33637b174d7ca2db00d47c85ff082020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15140-zhttps://doaj.org/toc/2041-1723Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.Carole TrzaskaSéverine AmandChristine BaillyCatherine LeroyVirginie MarchandEvelyne Duvernois-BerthetJean-Michel SaliouHana BenhabilesElisabeth WerkmeisterThierry ChassatRomain GuilbertDavid HannebiqueAnthony MourayMarie-Christine CopinPierre-Arthur MoreauEric AdriaenssensAndreas KulozikEric WesthofDavid TulasneYuri MotorinSylvie RebuffatFabrice LejeuneNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Carole Trzaska Séverine Amand Christine Bailly Catherine Leroy Virginie Marchand Evelyne Duvernois-Berthet Jean-Michel Saliou Hana Benhabiles Elisabeth Werkmeister Thierry Chassat Romain Guilbert David Hannebique Anthony Mouray Marie-Christine Copin Pierre-Arthur Moreau Eric Adriaenssens Andreas Kulozik Eric Westhof David Tulasne Yuri Motorin Sylvie Rebuffat Fabrice Lejeune 2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations |
| description |
Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity. |
| format |
article |
| author |
Carole Trzaska Séverine Amand Christine Bailly Catherine Leroy Virginie Marchand Evelyne Duvernois-Berthet Jean-Michel Saliou Hana Benhabiles Elisabeth Werkmeister Thierry Chassat Romain Guilbert David Hannebique Anthony Mouray Marie-Christine Copin Pierre-Arthur Moreau Eric Adriaenssens Andreas Kulozik Eric Westhof David Tulasne Yuri Motorin Sylvie Rebuffat Fabrice Lejeune |
| author_facet |
Carole Trzaska Séverine Amand Christine Bailly Catherine Leroy Virginie Marchand Evelyne Duvernois-Berthet Jean-Michel Saliou Hana Benhabiles Elisabeth Werkmeister Thierry Chassat Romain Guilbert David Hannebique Anthony Mouray Marie-Christine Copin Pierre-Arthur Moreau Eric Adriaenssens Andreas Kulozik Eric Westhof David Tulasne Yuri Motorin Sylvie Rebuffat Fabrice Lejeune |
| author_sort |
Carole Trzaska |
| title |
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations |
| title_short |
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations |
| title_full |
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations |
| title_fullStr |
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations |
| title_full_unstemmed |
2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations |
| title_sort |
2,6-diaminopurine as a highly potent corrector of uga nonsense mutations |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/970f33637b174d7ca2db00d47c85ff08 |
| work_keys_str_mv |
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| _version_ |
1718385947613069312 |