Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

Dopamine D2 receptor activity in the nucleus accumbens is associated with regulation of motivated responding. Here the authors show that overexpression of D2 receptors specifically in ventral striatal projection neurons leads to an increase in the willingness to work by reducing inhibitory transmiss...

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Autores principales:	Eduardo F. Gallo, Jozsef Meszaros, Jeremy D. Sherman, Muhammad O. Chohan, Eric Teboul, Claire S. Choi, Holly Moore, Jonathan A. Javitch, Christoph Kellendonk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9716d06b79b041318d69d2b9867976d1
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spelling	oai:doaj.org-article:9716d06b79b041318d69d2b9867976d12021-12-02T17:32:35ZAccumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum10.1038/s41467-018-03272-22041-1723https://doaj.org/article/9716d06b79b041318d69d2b9867976d12018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03272-2https://doaj.org/toc/2041-1723Dopamine D2 receptor activity in the nucleus accumbens is associated with regulation of motivated responding. Here the authors show that overexpression of D2 receptors specifically in ventral striatal projection neurons leads to an increase in the willingness to work by reducing inhibitory transmission to ventral pallidal neurons.Eduardo F. GalloJozsef MeszarosJeremy D. ShermanMuhammad O. ChohanEric TeboulClaire S. ChoiHolly MooreJonathan A. JavitchChristoph KellendonkNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eduardo F. Gallo Jozsef Meszaros Jeremy D. Sherman Muhammad O. Chohan Eric Teboul Claire S. Choi Holly Moore Jonathan A. Javitch Christoph Kellendonk Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
description	Dopamine D2 receptor activity in the nucleus accumbens is associated with regulation of motivated responding. Here the authors show that overexpression of D2 receptors specifically in ventral striatal projection neurons leads to an increase in the willingness to work by reducing inhibitory transmission to ventral pallidal neurons.
format	article
author	Eduardo F. Gallo Jozsef Meszaros Jeremy D. Sherman Muhammad O. Chohan Eric Teboul Claire S. Choi Holly Moore Jonathan A. Javitch Christoph Kellendonk
author_facet	Eduardo F. Gallo Jozsef Meszaros Jeremy D. Sherman Muhammad O. Chohan Eric Teboul Claire S. Choi Holly Moore Jonathan A. Javitch Christoph Kellendonk
author_sort	Eduardo F. Gallo
title	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_short	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_full	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_fullStr	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_full_unstemmed	Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
title_sort	accumbens dopamine d2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9716d06b79b041318d69d2b9867976d1
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Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

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