Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases
The development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal c...
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Nature Portfolio
2019
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oai:doaj.org-article:971f843531b644688afff75b88f273992021-12-02T15:35:58ZGenomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases10.1038/s41467-019-10987-32041-1723https://doaj.org/article/971f843531b644688afff75b88f273992019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10987-3https://doaj.org/toc/2041-1723The development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal cancer.Jing SunCheng WangYi ZhangLingyan XuWeijia FangYuping ZhuYi ZhengXiaofeng ChenXiju XieXinhua HuWeidong HuJingyu ZhengPing LiJian YuZhu MeiXiaomin CaiBiao WangZhibin HuYongqian ShuHongbing ShenYanhong GuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jing Sun Cheng Wang Yi Zhang Lingyan Xu Weijia Fang Yuping Zhu Yi Zheng Xiaofeng Chen Xiju Xie Xinhua Hu Weidong Hu Jingyu Zheng Ping Li Jian Yu Zhu Mei Xiaomin Cai Biao Wang Zhibin Hu Yongqian Shu Hongbing Shen Yanhong Gu Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| description |
The development of brain metastases is a lethal yet poorly understood event in the evolution of many cancers. Here, the authors perform whole-genome and whole-exome sequencing on matched normal, primary and metastatic tissue samples to explore the genomic features of brain metastases in colorectal cancer. |
| format |
article |
| author |
Jing Sun Cheng Wang Yi Zhang Lingyan Xu Weijia Fang Yuping Zhu Yi Zheng Xiaofeng Chen Xiju Xie Xinhua Hu Weidong Hu Jingyu Zheng Ping Li Jian Yu Zhu Mei Xiaomin Cai Biao Wang Zhibin Hu Yongqian Shu Hongbing Shen Yanhong Gu |
| author_facet |
Jing Sun Cheng Wang Yi Zhang Lingyan Xu Weijia Fang Yuping Zhu Yi Zheng Xiaofeng Chen Xiju Xie Xinhua Hu Weidong Hu Jingyu Zheng Ping Li Jian Yu Zhu Mei Xiaomin Cai Biao Wang Zhibin Hu Yongqian Shu Hongbing Shen Yanhong Gu |
| author_sort |
Jing Sun |
| title |
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_short |
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_full |
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_fullStr |
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_full_unstemmed |
Genomic signatures reveal DNA damage response deficiency in colorectal cancer brain metastases |
| title_sort |
genomic signatures reveal dna damage response deficiency in colorectal cancer brain metastases |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/971f843531b644688afff75b88f27399 |
| work_keys_str_mv |
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