A genome-wide association study of neuroticism in a population-based sample.
Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest assoc...
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2010
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oai:doaj.org-article:97239484827249bd95524d1bf1ae65592021-12-02T20:20:12ZA genome-wide association study of neuroticism in a population-based sample.1932-620310.1371/journal.pone.0011504https://doaj.org/article/97239484827249bd95524d1bf1ae65592010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20634892/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of population stratification, corrected using one principal component, and some cryptic kinship that required no correction. NKAIN2 showed suggestive evidence of association with neuroticism as a main effect (p < 10(-6)) and GPC6 showed suggestive evidence for interaction with age (p approximately = 10(-7)). We found support for one previously-reported association (PDE4D), but failed to replicate other recent reports. These results suggest common SNP variation does not strongly influence neuroticism. Our study was powered to detect almost all SNPs explaining at least 2% of heritability, and so our results effectively exclude the existence of loci having a major effect on neuroticism.Federico C F CalboliFederica TozziNicholas W GalweyAthos AntoniadesVincent MooserMartin PreisigPeter VollenweiderDawn WaterworthGerard WaeberMichael R JohnsonPierandrea MugliaDavid J BaldingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 7, p e11504 (2010) |
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Medicine R Science Q |
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Medicine R Science Q Federico C F Calboli Federica Tozzi Nicholas W Galwey Athos Antoniades Vincent Mooser Martin Preisig Peter Vollenweider Dawn Waterworth Gerard Waeber Michael R Johnson Pierandrea Muglia David J Balding A genome-wide association study of neuroticism in a population-based sample. |
| description |
Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of population stratification, corrected using one principal component, and some cryptic kinship that required no correction. NKAIN2 showed suggestive evidence of association with neuroticism as a main effect (p < 10(-6)) and GPC6 showed suggestive evidence for interaction with age (p approximately = 10(-7)). We found support for one previously-reported association (PDE4D), but failed to replicate other recent reports. These results suggest common SNP variation does not strongly influence neuroticism. Our study was powered to detect almost all SNPs explaining at least 2% of heritability, and so our results effectively exclude the existence of loci having a major effect on neuroticism. |
| format |
article |
| author |
Federico C F Calboli Federica Tozzi Nicholas W Galwey Athos Antoniades Vincent Mooser Martin Preisig Peter Vollenweider Dawn Waterworth Gerard Waeber Michael R Johnson Pierandrea Muglia David J Balding |
| author_facet |
Federico C F Calboli Federica Tozzi Nicholas W Galwey Athos Antoniades Vincent Mooser Martin Preisig Peter Vollenweider Dawn Waterworth Gerard Waeber Michael R Johnson Pierandrea Muglia David J Balding |
| author_sort |
Federico C F Calboli |
| title |
A genome-wide association study of neuroticism in a population-based sample. |
| title_short |
A genome-wide association study of neuroticism in a population-based sample. |
| title_full |
A genome-wide association study of neuroticism in a population-based sample. |
| title_fullStr |
A genome-wide association study of neuroticism in a population-based sample. |
| title_full_unstemmed |
A genome-wide association study of neuroticism in a population-based sample. |
| title_sort |
genome-wide association study of neuroticism in a population-based sample. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2010 |
| url |
https://doaj.org/article/97239484827249bd95524d1bf1ae6559 |
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