Pharmacological effects of ex vivo mesenchymal stem cell immunotherapy in patients with acute kidney injury and underlying systemic inflammation

Pharmacological effects of ex vivo mesenchymal stem cell immunotherapy in patients with acute kidney injury and underlying systemic inflammation

Abstract Mesenchymal stem cells (MSCs) have natural immunoregulatory functions that have been explored for medicinal use as a cell therapy with limited success. A phase Ib study was conducted to evaluate the safety and immunoregulatory mechanism of action of MSCs using a novel ex vivo product (SBI‐1...

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Main Authors: Madhav Swaminathan, Nelson Kopyt, Mohamed G. Atta, Jai Radhakrishnan, Kausik Umanath, Sunny Nguyen, Brian O'Rourke, Ashley Allen, Natalie Vaninov, Arno Tilles, Elizabeth LaPointe, Andrew Blair, Chris Gemmiti, Brian Miller, Biju Parekkadan, Rita N. Barcia
Format: article
Language:EN
Published: Wiley 2021
Subjects:
adult stem cells
cellular therapy
clinical trials
cytokines
immunotherapy
lymphocytes
Medicine (General)
R5-920
Cytology
QH573-671
Online Access:https://doaj.org/article/972534fc7b2b461b98b88dca1a0d590f
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https://doaj.org/article/972534fc7b2b461b98b88dca1a0d590f

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