Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia

Chemoresistance and relapse are main limitations in the treatment of acute lymphoblastic leukemia (ALL). Here, the authors identify Quinacrine (QC) as a sensitizer for Cytarabine (AraC) and establish a QC-CASIN regimen to improve leukemia eradication in ALL.

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Autores principales:	Limei Wu, Srinivas Chatla, Qiqi Lin, Fabliha Ahmed Chowdhury, Werner Geldenhuys, Wei Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97269be323ee4237991e7229e073c7fe
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spelling	oai:doaj.org-article:97269be323ee4237991e7229e073c7fe2021-11-28T12:33:49ZQuinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia10.1038/s41467-021-27300-w2041-1723https://doaj.org/article/97269be323ee4237991e7229e073c7fe2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27300-whttps://doaj.org/toc/2041-1723Chemoresistance and relapse are main limitations in the treatment of acute lymphoblastic leukemia (ALL). Here, the authors identify Quinacrine (QC) as a sensitizer for Cytarabine (AraC) and establish a QC-CASIN regimen to improve leukemia eradication in ALL.Limei WuSrinivas ChatlaQiqi LinFabliha Ahmed ChowdhuryWerner GeldenhuysWei DuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Limei Wu Srinivas Chatla Qiqi Lin Fabliha Ahmed Chowdhury Werner Geldenhuys Wei Du Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia
description	Chemoresistance and relapse are main limitations in the treatment of acute lymphoblastic leukemia (ALL). Here, the authors identify Quinacrine (QC) as a sensitizer for Cytarabine (AraC) and establish a QC-CASIN regimen to improve leukemia eradication in ALL.
format	article
author	Limei Wu Srinivas Chatla Qiqi Lin Fabliha Ahmed Chowdhury Werner Geldenhuys Wei Du
author_facet	Limei Wu Srinivas Chatla Qiqi Lin Fabliha Ahmed Chowdhury Werner Geldenhuys Wei Du
author_sort	Limei Wu
title	Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia
title_short	Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia
title_full	Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia
title_fullStr	Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia
title_full_unstemmed	Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia
title_sort	quinacrine-casin combination overcomes chemoresistance in human acute lymphoid leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97269be323ee4237991e7229e073c7fe
work_keys_str_mv	AT limeiwu quinacrinecasincombinationovercomeschemoresistanceinhumanacutelymphoidleukemia AT srinivaschatla quinacrinecasincombinationovercomeschemoresistanceinhumanacutelymphoidleukemia AT qiqilin quinacrinecasincombinationovercomeschemoresistanceinhumanacutelymphoidleukemia AT fablihaahmedchowdhury quinacrinecasincombinationovercomeschemoresistanceinhumanacutelymphoidleukemia AT wernergeldenhuys quinacrinecasincombinationovercomeschemoresistanceinhumanacutelymphoidleukemia AT weidu quinacrinecasincombinationovercomeschemoresistanceinhumanacutelymphoidleukemia
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Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia

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