Survival Comes at a Cost: A Coevolution of Phage and Its Host Leads to Phage Resistance and Antibiotic Sensitivity of Pseudomonas aeruginosa Multidrug Resistant Strains

Survival Comes at a Cost: A Coevolution of Phage and Its Host Leads to Phage Resistance and Antibiotic Sensitivity of Pseudomonas aeruginosa Multidrug Resistant Strains

The increasing ineffectiveness of traditional antibiotics and the rise of multidrug resistant (MDR) bacteria have necessitated the revival of bacteriophage (phage) therapy. However, bacteria might also evolve resistance against phages. Phages and their bacterial hosts coexist in nature, resulting in...

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Bibliographic Details
Main Authors: Sarshad Koderi Valappil, Prateek Shetty, Zoltán Deim, Gabriella Terhes, Edit Urbán, Sándor Váczi, Roland Patai, Tamás Polgár, Botond Zsombor Pertics, György Schneider, Tamás Kovács, Gábor Rákhely
Format: article
Language:EN
Published: Frontiers Media S.A. 2021
Subjects:
bacteriophage therapy
combined treatment
phage resistance
phage-provoked sequential genomic mutation/deletion
MexXY-OprM efflux system
Microbiology
QR1-502
Online Access:https://doaj.org/article/972bd7a2e05c463dbeb7a8f041c1776c
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