α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease

α-Synuclein-specific T cell reactivity is preferentially associated with Parkinson’s disease (PD) patients, but the temporal relation with diagnosis was previously unknown. This study reveals that α-syn-reactive T cells are highest before and shortly after diagnosis of motor PD, and then decrease....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cecilia S. Lindestam Arlehamn, Rekha Dhanwani, John Pham, Rebecca Kuan, April Frazier, Juliana Rezende Dutra, Elizabeth Phillips, Simon Mallal, Mario Roederer, Karen S. Marder, Amy W. Amara, David G. Standaert, Jennifer G. Goldman, Irene Litvan, Bjoern Peters, David Sulzer, Alessandro Sette
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9731c07b2438479d8928e5d35c33b9a6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9731c07b2438479d8928e5d35c33b9a6
record_format	dspace
spelling	oai:doaj.org-article:9731c07b2438479d8928e5d35c33b9a62021-12-02T14:40:27Zα-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease10.1038/s41467-020-15626-w2041-1723https://doaj.org/article/9731c07b2438479d8928e5d35c33b9a62020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15626-whttps://doaj.org/toc/2041-1723α-Synuclein-specific T cell reactivity is preferentially associated with Parkinson’s disease (PD) patients, but the temporal relation with diagnosis was previously unknown. This study reveals that α-syn-reactive T cells are highest before and shortly after diagnosis of motor PD, and then decrease.Cecilia S. Lindestam ArlehamnRekha DhanwaniJohn PhamRebecca KuanApril FrazierJuliana Rezende DutraElizabeth PhillipsSimon MallalMario RoedererKaren S. MarderAmy W. AmaraDavid G. StandaertJennifer G. GoldmanIrene LitvanBjoern PetersDavid SulzerAlessandro SetteNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cecilia S. Lindestam Arlehamn Rekha Dhanwani John Pham Rebecca Kuan April Frazier Juliana Rezende Dutra Elizabeth Phillips Simon Mallal Mario Roederer Karen S. Marder Amy W. Amara David G. Standaert Jennifer G. Goldman Irene Litvan Bjoern Peters David Sulzer Alessandro Sette α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
description	α-Synuclein-specific T cell reactivity is preferentially associated with Parkinson’s disease (PD) patients, but the temporal relation with diagnosis was previously unknown. This study reveals that α-syn-reactive T cells are highest before and shortly after diagnosis of motor PD, and then decrease.
format	article
author	Cecilia S. Lindestam Arlehamn Rekha Dhanwani John Pham Rebecca Kuan April Frazier Juliana Rezende Dutra Elizabeth Phillips Simon Mallal Mario Roederer Karen S. Marder Amy W. Amara David G. Standaert Jennifer G. Goldman Irene Litvan Bjoern Peters David Sulzer Alessandro Sette
author_facet	Cecilia S. Lindestam Arlehamn Rekha Dhanwani John Pham Rebecca Kuan April Frazier Juliana Rezende Dutra Elizabeth Phillips Simon Mallal Mario Roederer Karen S. Marder Amy W. Amara David G. Standaert Jennifer G. Goldman Irene Litvan Bjoern Peters David Sulzer Alessandro Sette
author_sort	Cecilia S. Lindestam Arlehamn
title	α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
title_short	α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
title_full	α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
title_fullStr	α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
title_full_unstemmed	α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease
title_sort	α-synuclein-specific t cell reactivity is associated with preclinical and early parkinson’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9731c07b2438479d8928e5d35c33b9a6
work_keys_str_mv	AT ceciliaslindestamarlehamn asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT rekhadhanwani asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT johnpham asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT rebeccakuan asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT aprilfrazier asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT julianarezendedutra asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT elizabethphillips asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT simonmallal asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT marioroederer asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT karensmarder asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT amywamara asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT davidgstandaert asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT jenniferggoldman asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT irenelitvan asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT bjoernpeters asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT davidsulzer asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease AT alessandrosette asynucleinspecifictcellreactivityisassociatedwithpreclinicalandearlyparkinsonsdisease
_version_	1718390312054816768

α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease

Ejemplares similares