Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease

Abstract We investigated the association between body weight variability and the risks of cardiovascular disease and mortality in patients with nonalcoholic fatty liver disease (NAFLD) using large-scale, nationwide cohort data. We included 726,736 individuals with NAFLD who underwent a health examin...

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Autores principales:	Mi Na Kim, Kyungdo Han, Juhwan Yoo, Yeonjung Ha, Young Eun Chon, Ju Ho Lee, Tracey G. Simon, Andrew T. Chan, Seong Gyu Hwang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9731fb4038c74659bb692043c7f4feee
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spelling	oai:doaj.org-article:9731fb4038c74659bb692043c7f4feee2021-12-02T13:41:34ZBody weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease10.1038/s41598-021-88733-32045-2322https://doaj.org/article/9731fb4038c74659bb692043c7f4feee2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88733-3https://doaj.org/toc/2045-2322Abstract We investigated the association between body weight variability and the risks of cardiovascular disease and mortality in patients with nonalcoholic fatty liver disease (NAFLD) using large-scale, nationwide cohort data. We included 726,736 individuals with NAFLD who underwent a health examination between 2009 and 2010. NAFLD was defined as a fatty liver index ≥ 60, after excluding significant alcohol intake, viral hepatitis, and liver cirrhosis. Body weight variability was assessed using four indices, including variability independent of the mean (VIM). During a median 8.1-year follow-up, we documented 11,358, 14,714, and 22,164 cases of myocardial infarction (MI), stroke, and all-cause mortality, respectively. Body weight variability was associated with an increased risk of MI, stroke, and mortality after adjusting for confounding variables. The hazard ratios (HRs) (95% confidence intervals) for the highest quartile, compared with the lowest quartile, of VIM for body weight were 1.15 (1.10–1.20), 1.22 (1.18–1.26), and 1.56 (1.53–1.62) for MI, stroke, and all-cause mortality, respectively. Body weight variability was associated with increased risks of MI, stroke, and all-cause mortality in NAFLD patients. Appropriate interventions to maintain a stable weight could positively affect health outcomes in NAFLD patients.Mi Na KimKyungdo HanJuhwan YooYeonjung HaYoung Eun ChonJu Ho LeeTracey G. SimonAndrew T. ChanSeong Gyu HwangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mi Na Kim Kyungdo Han Juhwan Yoo Yeonjung Ha Young Eun Chon Ju Ho Lee Tracey G. Simon Andrew T. Chan Seong Gyu Hwang Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease
description	Abstract We investigated the association between body weight variability and the risks of cardiovascular disease and mortality in patients with nonalcoholic fatty liver disease (NAFLD) using large-scale, nationwide cohort data. We included 726,736 individuals with NAFLD who underwent a health examination between 2009 and 2010. NAFLD was defined as a fatty liver index ≥ 60, after excluding significant alcohol intake, viral hepatitis, and liver cirrhosis. Body weight variability was assessed using four indices, including variability independent of the mean (VIM). During a median 8.1-year follow-up, we documented 11,358, 14,714, and 22,164 cases of myocardial infarction (MI), stroke, and all-cause mortality, respectively. Body weight variability was associated with an increased risk of MI, stroke, and mortality after adjusting for confounding variables. The hazard ratios (HRs) (95% confidence intervals) for the highest quartile, compared with the lowest quartile, of VIM for body weight were 1.15 (1.10–1.20), 1.22 (1.18–1.26), and 1.56 (1.53–1.62) for MI, stroke, and all-cause mortality, respectively. Body weight variability was associated with increased risks of MI, stroke, and all-cause mortality in NAFLD patients. Appropriate interventions to maintain a stable weight could positively affect health outcomes in NAFLD patients.
format	article
author	Mi Na Kim Kyungdo Han Juhwan Yoo Yeonjung Ha Young Eun Chon Ju Ho Lee Tracey G. Simon Andrew T. Chan Seong Gyu Hwang
author_facet	Mi Na Kim Kyungdo Han Juhwan Yoo Yeonjung Ha Young Eun Chon Ju Ho Lee Tracey G. Simon Andrew T. Chan Seong Gyu Hwang
author_sort	Mi Na Kim
title	Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease
title_short	Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease
title_full	Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease
title_fullStr	Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease
title_full_unstemmed	Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease
title_sort	body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9731fb4038c74659bb692043c7f4feee
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Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease

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