Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice

During the maternal-to-zygotic transition there is degradation of maternal proteins via the ubiquitin-proteasome system (UPS). Here, the authors show that in the embryo the maternally inherited epigenetic factor DPPA3/Stella/PGC7 is cleavage by the UPS and controls intracellular trafficking.

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Autores principales:	Seung-Wook Shin, Edgar John Vogt, Maria Jimenez-Movilla, Boris Baibakov, Jurrien Dean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/973311f9c5ad4366a689137556ac9020
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spelling	oai:doaj.org-article:973311f9c5ad4366a689137556ac90202021-12-02T14:40:58ZCytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice10.1038/s41467-017-01387-62041-1723https://doaj.org/article/973311f9c5ad4366a689137556ac90202017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01387-6https://doaj.org/toc/2041-1723During the maternal-to-zygotic transition there is degradation of maternal proteins via the ubiquitin-proteasome system (UPS). Here, the authors show that in the embryo the maternally inherited epigenetic factor DPPA3/Stella/PGC7 is cleavage by the UPS and controls intracellular trafficking.Seung-Wook ShinEdgar John VogtMaria Jimenez-MovillaBoris BaibakovJurrien DeanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seung-Wook Shin Edgar John Vogt Maria Jimenez-Movilla Boris Baibakov Jurrien Dean Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice
description	During the maternal-to-zygotic transition there is degradation of maternal proteins via the ubiquitin-proteasome system (UPS). Here, the authors show that in the embryo the maternally inherited epigenetic factor DPPA3/Stella/PGC7 is cleavage by the UPS and controls intracellular trafficking.
format	article
author	Seung-Wook Shin Edgar John Vogt Maria Jimenez-Movilla Boris Baibakov Jurrien Dean
author_facet	Seung-Wook Shin Edgar John Vogt Maria Jimenez-Movilla Boris Baibakov Jurrien Dean
author_sort	Seung-Wook Shin
title	Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice
title_short	Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice
title_full	Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice
title_fullStr	Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice
title_full_unstemmed	Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice
title_sort	cytoplasmic cleavage of dppa3 is required for intracellular trafficking and cleavage-stage development in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/973311f9c5ad4366a689137556ac9020
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Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice

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