Rapid active zone remodeling consolidates presynaptic potentiation

Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter release, and identify Unc13 as a presynaptic molecu...

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Autores principales:	Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9733b2fe50774e4e995b69653b092187
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spelling	oai:doaj.org-article:9733b2fe50774e4e995b69653b0921872021-12-02T14:39:36ZRapid active zone remodeling consolidates presynaptic potentiation10.1038/s41467-019-08977-62041-1723https://doaj.org/article/9733b2fe50774e4e995b69653b0921872019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08977-6https://doaj.org/toc/2041-1723Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter release, and identify Unc13 as a presynaptic molecular target for homeostatic potentiation and learning.Mathias A. BöhmeAnthony W. McCarthyAndreas T. GrasskampChristine B. BeuschelPragya GoelMeida JusyteDesiree LaberSheng HuangUlises ReyAstrid G. PetzoldtMartin LehmannFabian GöttfertPejmun HaghighiStefan W. HellDavid OwaldDion DickmanStephan J. SigristAlexander M. WalterNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mathias A. Böhme Anthony W. McCarthy Andreas T. Grasskamp Christine B. Beuschel Pragya Goel Meida Jusyte Desiree Laber Sheng Huang Ulises Rey Astrid G. Petzoldt Martin Lehmann Fabian Göttfert Pejmun Haghighi Stefan W. Hell David Owald Dion Dickman Stephan J. Sigrist Alexander M. Walter Rapid active zone remodeling consolidates presynaptic potentiation
description	Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter release, and identify Unc13 as a presynaptic molecular target for homeostatic potentiation and learning.
format	article
author	Mathias A. Böhme Anthony W. McCarthy Andreas T. Grasskamp Christine B. Beuschel Pragya Goel Meida Jusyte Desiree Laber Sheng Huang Ulises Rey Astrid G. Petzoldt Martin Lehmann Fabian Göttfert Pejmun Haghighi Stefan W. Hell David Owald Dion Dickman Stephan J. Sigrist Alexander M. Walter
author_facet	Mathias A. Böhme Anthony W. McCarthy Andreas T. Grasskamp Christine B. Beuschel Pragya Goel Meida Jusyte Desiree Laber Sheng Huang Ulises Rey Astrid G. Petzoldt Martin Lehmann Fabian Göttfert Pejmun Haghighi Stefan W. Hell David Owald Dion Dickman Stephan J. Sigrist Alexander M. Walter
author_sort	Mathias A. Böhme
title	Rapid active zone remodeling consolidates presynaptic potentiation
title_short	Rapid active zone remodeling consolidates presynaptic potentiation
title_full	Rapid active zone remodeling consolidates presynaptic potentiation
title_fullStr	Rapid active zone remodeling consolidates presynaptic potentiation
title_full_unstemmed	Rapid active zone remodeling consolidates presynaptic potentiation
title_sort	rapid active zone remodeling consolidates presynaptic potentiation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9733b2fe50774e4e995b69653b092187
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_version_	1718390547280822272

Rapid active zone remodeling consolidates presynaptic potentiation

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