Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, wh...

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Autores principales: Tobias Weinberger, Dena Esfandyari, Denise Messerer, Gulce Percin, Christian Schleifer, Raffael Thaler, Lulu Liu, Christopher Stremmel, Vanessa Schneider, Ronald J. Vagnozzi, Jennifer Schwanenkamp, Maximilian Fischer, Katrin Busch, Kay Klapproth, Hellen Ishikawa-Ankerhold, Lukas Klösges, Anna Titova, Jeffery D. Molkentin, Yasuhiro Kobayashi, Stefan Engelhardt, Steffen Massberg, Claudia Waskow, Elisa Gomez Perdiguero, Christian Schulz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/9736be91c4674079bfa53c6a81afee95
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Sumario:Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, while arterial macrophages of yolk sac origin carry out tissue repair.

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