Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, wh...

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Autores principales:	Tobias Weinberger, Dena Esfandyari, Denise Messerer, Gulce Percin, Christian Schleifer, Raffael Thaler, Lulu Liu, Christopher Stremmel, Vanessa Schneider, Ronald J. Vagnozzi, Jennifer Schwanenkamp, Maximilian Fischer, Katrin Busch, Kay Klapproth, Hellen Ishikawa-Ankerhold, Lukas Klösges, Anna Titova, Jeffery D. Molkentin, Yasuhiro Kobayashi, Stefan Engelhardt, Steffen Massberg, Claudia Waskow, Elisa Gomez Perdiguero, Christian Schulz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9736be91c4674079bfa53c6a81afee95
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spelling	oai:doaj.org-article:9736be91c4674079bfa53c6a81afee952021-12-02T14:55:09ZOntogeny of arterial macrophages defines their functions in homeostasis and inflammation10.1038/s41467-020-18287-x2041-1723https://doaj.org/article/9736be91c4674079bfa53c6a81afee952020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18287-xhttps://doaj.org/toc/2041-1723Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, while arterial macrophages of yolk sac origin carry out tissue repair.Tobias WeinbergerDena EsfandyariDenise MessererGulce PercinChristian SchleiferRaffael ThalerLulu LiuChristopher StremmelVanessa SchneiderRonald J. VagnozziJennifer SchwanenkampMaximilian FischerKatrin BuschKay KlapprothHellen Ishikawa-AnkerholdLukas KlösgesAnna TitovaJeffery D. MolkentinYasuhiro KobayashiStefan EngelhardtSteffen MassbergClaudia WaskowElisa Gomez PerdigueroChristian SchulzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tobias Weinberger Dena Esfandyari Denise Messerer Gulce Percin Christian Schleifer Raffael Thaler Lulu Liu Christopher Stremmel Vanessa Schneider Ronald J. Vagnozzi Jennifer Schwanenkamp Maximilian Fischer Katrin Busch Kay Klapproth Hellen Ishikawa-Ankerhold Lukas Klösges Anna Titova Jeffery D. Molkentin Yasuhiro Kobayashi Stefan Engelhardt Steffen Massberg Claudia Waskow Elisa Gomez Perdiguero Christian Schulz Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
description	Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating monocytes are recruited to maintain homeostasis, while arterial macrophages of yolk sac origin carry out tissue repair.
format	article
author	Tobias Weinberger Dena Esfandyari Denise Messerer Gulce Percin Christian Schleifer Raffael Thaler Lulu Liu Christopher Stremmel Vanessa Schneider Ronald J. Vagnozzi Jennifer Schwanenkamp Maximilian Fischer Katrin Busch Kay Klapproth Hellen Ishikawa-Ankerhold Lukas Klösges Anna Titova Jeffery D. Molkentin Yasuhiro Kobayashi Stefan Engelhardt Steffen Massberg Claudia Waskow Elisa Gomez Perdiguero Christian Schulz
author_facet	Tobias Weinberger Dena Esfandyari Denise Messerer Gulce Percin Christian Schleifer Raffael Thaler Lulu Liu Christopher Stremmel Vanessa Schneider Ronald J. Vagnozzi Jennifer Schwanenkamp Maximilian Fischer Katrin Busch Kay Klapproth Hellen Ishikawa-Ankerhold Lukas Klösges Anna Titova Jeffery D. Molkentin Yasuhiro Kobayashi Stefan Engelhardt Steffen Massberg Claudia Waskow Elisa Gomez Perdiguero Christian Schulz
author_sort	Tobias Weinberger
title	Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
title_short	Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
title_full	Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
title_fullStr	Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
title_full_unstemmed	Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
title_sort	ontogeny of arterial macrophages defines their functions in homeostasis and inflammation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9736be91c4674079bfa53c6a81afee95
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Ontogeny of arterial macrophages defines their functions in homeostasis and inflammation

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