Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production
Some strains of Mycobacterium tuberculosis seem to be able to avoid host defense systems. Here the authors stratify patients by severity of tuberculosis and find correlations with the level of IL-1β production by macrophages exposed to these isolates.
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2020
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oai:doaj.org-article:9739f22b341d45e887d3375a55c3b04a2021-12-02T14:43:01ZMycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production10.1038/s41467-020-15832-62041-1723https://doaj.org/article/9739f22b341d45e887d3375a55c3b04a2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15832-6https://doaj.org/toc/2041-1723Some strains of Mycobacterium tuberculosis seem to be able to avoid host defense systems. Here the authors stratify patients by severity of tuberculosis and find correlations with the level of IL-1β production by macrophages exposed to these isolates.Jeremy SousaBaltazar CáAna Raquel MaceirasLuisa Simões-CostaKaori L. FonsecaAna Isabel FernandesAngélica RamosTeresa CarvalhoLeandro BarrosCarlos MagalhãesÁlvaro Chiner-OmsHenrique MachadoMaria Isabel VeigaAlbel SinghRui PereiraAntónio AmorimJorge VieiraCristina P. VieiraApoorva BhattFernando RodriguesPedro N. S. RodriguesSebastien GagneuxAntónio Gil CastroJoão Tiago GuimarãesHelder Novais BastosNuno S. OsórioIñaki ComasMargarida SaraivaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jeremy Sousa Baltazar Cá Ana Raquel Maceiras Luisa Simões-Costa Kaori L. Fonseca Ana Isabel Fernandes Angélica Ramos Teresa Carvalho Leandro Barros Carlos Magalhães Álvaro Chiner-Oms Henrique Machado Maria Isabel Veiga Albel Singh Rui Pereira António Amorim Jorge Vieira Cristina P. Vieira Apoorva Bhatt Fernando Rodrigues Pedro N. S. Rodrigues Sebastien Gagneux António Gil Castro João Tiago Guimarães Helder Novais Bastos Nuno S. Osório Iñaki Comas Margarida Saraiva Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production |
| description |
Some strains of Mycobacterium tuberculosis seem to be able to avoid host defense systems. Here the authors stratify patients by severity of tuberculosis and find correlations with the level of IL-1β production by macrophages exposed to these isolates. |
| format |
article |
| author |
Jeremy Sousa Baltazar Cá Ana Raquel Maceiras Luisa Simões-Costa Kaori L. Fonseca Ana Isabel Fernandes Angélica Ramos Teresa Carvalho Leandro Barros Carlos Magalhães Álvaro Chiner-Oms Henrique Machado Maria Isabel Veiga Albel Singh Rui Pereira António Amorim Jorge Vieira Cristina P. Vieira Apoorva Bhatt Fernando Rodrigues Pedro N. S. Rodrigues Sebastien Gagneux António Gil Castro João Tiago Guimarães Helder Novais Bastos Nuno S. Osório Iñaki Comas Margarida Saraiva |
| author_facet |
Jeremy Sousa Baltazar Cá Ana Raquel Maceiras Luisa Simões-Costa Kaori L. Fonseca Ana Isabel Fernandes Angélica Ramos Teresa Carvalho Leandro Barros Carlos Magalhães Álvaro Chiner-Oms Henrique Machado Maria Isabel Veiga Albel Singh Rui Pereira António Amorim Jorge Vieira Cristina P. Vieira Apoorva Bhatt Fernando Rodrigues Pedro N. S. Rodrigues Sebastien Gagneux António Gil Castro João Tiago Guimarães Helder Novais Bastos Nuno S. Osório Iñaki Comas Margarida Saraiva |
| author_sort |
Jeremy Sousa |
| title |
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production |
| title_short |
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production |
| title_full |
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production |
| title_fullStr |
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production |
| title_full_unstemmed |
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production |
| title_sort |
mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates il-1β production |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/9739f22b341d45e887d3375a55c3b04a |
| work_keys_str_mv |
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| _version_ |
1718389583781036032 |