Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis

Abstract It is particularly important to provide precise therapies and understand tumor heterogeneity based on the molecular typing of mutational landscape. However, the landscape of somatic mutations in different subtypes of advanced breast cancer (ABC) is largely unknown. We applied target-region...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zongbi Yi, Fei Ma, Chunxiao Li, Rongrong Chen, Lifang Yuan, Xiaoying Sun, Xiuwen Guan, Lixi Li, Binliang Liu, Yanfang Guan, Haili Qian, Binghe Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/973dd7dd2c314ca3a0485a0ebd36ac6f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:973dd7dd2c314ca3a0485a0ebd36ac6f
record_format	dspace
spelling	oai:doaj.org-article:973dd7dd2c314ca3a0485a0ebd36ac6f2021-12-02T11:52:21ZLandscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis10.1038/s41598-017-06327-42045-2322https://doaj.org/article/973dd7dd2c314ca3a0485a0ebd36ac6f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06327-4https://doaj.org/toc/2045-2322Abstract It is particularly important to provide precise therapies and understand tumor heterogeneity based on the molecular typing of mutational landscape. However, the landscape of somatic mutations in different subtypes of advanced breast cancer (ABC) is largely unknown. We applied target-region capture deep sequencing to determine the frequency and spectrum of common cancer-related gene mutations in circulating tumor DNA (ctDNA) among different ABC subtypes and analyze their association with clinical features. In this retrospective study of 100 female advanced breast cancer patients, 96 (96.0%) had somatic genomic alterations in ctDNA, including copy number variants and point mutations. The results revealed that different subtypes of ABC have distinct features in terms of genetic alterations. Multivariate regression analyses revealed that the number of somatic mutations increased with the line of endocrine therapy and the fractions of trunk mutations was positive associated with the line of target therapy.Zongbi YiFei MaChunxiao LiRongrong ChenLifang YuanXiaoying SunXiuwen GuanLixi LiBinliang LiuYanfang GuanHaili QianBinghe XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zongbi Yi Fei Ma Chunxiao Li Rongrong Chen Lifang Yuan Xiaoying Sun Xiuwen Guan Lixi Li Binliang Liu Yanfang Guan Haili Qian Binghe Xu Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis
description	Abstract It is particularly important to provide precise therapies and understand tumor heterogeneity based on the molecular typing of mutational landscape. However, the landscape of somatic mutations in different subtypes of advanced breast cancer (ABC) is largely unknown. We applied target-region capture deep sequencing to determine the frequency and spectrum of common cancer-related gene mutations in circulating tumor DNA (ctDNA) among different ABC subtypes and analyze their association with clinical features. In this retrospective study of 100 female advanced breast cancer patients, 96 (96.0%) had somatic genomic alterations in ctDNA, including copy number variants and point mutations. The results revealed that different subtypes of ABC have distinct features in terms of genetic alterations. Multivariate regression analyses revealed that the number of somatic mutations increased with the line of endocrine therapy and the fractions of trunk mutations was positive associated with the line of target therapy.
format	article
author	Zongbi Yi Fei Ma Chunxiao Li Rongrong Chen Lifang Yuan Xiaoying Sun Xiuwen Guan Lixi Li Binliang Liu Yanfang Guan Haili Qian Binghe Xu
author_facet	Zongbi Yi Fei Ma Chunxiao Li Rongrong Chen Lifang Yuan Xiaoying Sun Xiuwen Guan Lixi Li Binliang Liu Yanfang Guan Haili Qian Binghe Xu
author_sort	Zongbi Yi
title	Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis
title_short	Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis
title_full	Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis
title_fullStr	Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis
title_full_unstemmed	Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis
title_sort	landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor dna analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/973dd7dd2c314ca3a0485a0ebd36ac6f
work_keys_str_mv	AT zongbiyi landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT feima landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT chunxiaoli landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT rongrongchen landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT lifangyuan landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT xiaoyingsun landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT xiuwenguan landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT lixili landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT binliangliu landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT yanfangguan landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT hailiqian landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis AT binghexu landscapeofsomaticmutationsindifferentsubtypesofadvancedbreastcancerwithcirculatingtumordnaanalysis
_version_	1718395059380944896

Landscape of somatic mutations in different subtypes of advanced breast cancer with circulating tumor DNA analysis

Ejemplares similares