Is a persistent global bias necessary for the establishment of planar cell polarity?

Planar cell polarity (PCP)--the coordinated polarisation of a whole field of cells within the plane of a tissue-relies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local module that aligns the axis of polarisation of neighbourin...

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Autores principales:	Sabine Fischer, Paul Houston, Nicholas A M Monk, Markus R Owen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/973eee905f4f4617a5a7cf21a628e49a
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spelling	oai:doaj.org-article:973eee905f4f4617a5a7cf21a628e49a2021-11-18T07:50:13ZIs a persistent global bias necessary for the establishment of planar cell polarity?1932-620310.1371/journal.pone.0060064https://doaj.org/article/973eee905f4f4617a5a7cf21a628e49a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23593163/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Planar cell polarity (PCP)--the coordinated polarisation of a whole field of cells within the plane of a tissue-relies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local module that aligns the axis of polarisation of neighbouring cells, and a readout module that directs the correct outgrowth of PCP-regulated structures such as hairs and bristles. While much is known about the molecular components that are required for PCP, the functional details of--and interactions between--the modules remain unclear. In this work, we perform a mathematical and computational analysis of two previously proposed computational models of the local module (Amonlirdviman et al., Science, 307, 2005; Le Garrec et al., Dev. Dyn., 235, 2006). Both models can reproduce wild-type and mutant phenotypes of PCP observed in the Drosophila wing under the assumption that a tissue-wide polarity cue from the global module persists throughout the development of PCP. We demonstrate that both models can also generate tissue-level PCP when provided with only a transient initial polarity cue. However, in these models such transient cues are not sufficient to ensure robustness of the resulting cellular polarisation.Sabine FischerPaul HoustonNicholas A M MonkMarkus R OwenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60064 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sabine Fischer Paul Houston Nicholas A M Monk Markus R Owen Is a persistent global bias necessary for the establishment of planar cell polarity?
description	Planar cell polarity (PCP)--the coordinated polarisation of a whole field of cells within the plane of a tissue-relies on the interaction of three modules: a global module that couples individual cellular polarity to the tissue axis, a local module that aligns the axis of polarisation of neighbouring cells, and a readout module that directs the correct outgrowth of PCP-regulated structures such as hairs and bristles. While much is known about the molecular components that are required for PCP, the functional details of--and interactions between--the modules remain unclear. In this work, we perform a mathematical and computational analysis of two previously proposed computational models of the local module (Amonlirdviman et al., Science, 307, 2005; Le Garrec et al., Dev. Dyn., 235, 2006). Both models can reproduce wild-type and mutant phenotypes of PCP observed in the Drosophila wing under the assumption that a tissue-wide polarity cue from the global module persists throughout the development of PCP. We demonstrate that both models can also generate tissue-level PCP when provided with only a transient initial polarity cue. However, in these models such transient cues are not sufficient to ensure robustness of the resulting cellular polarisation.
format	article
author	Sabine Fischer Paul Houston Nicholas A M Monk Markus R Owen
author_facet	Sabine Fischer Paul Houston Nicholas A M Monk Markus R Owen
author_sort	Sabine Fischer
title	Is a persistent global bias necessary for the establishment of planar cell polarity?
title_short	Is a persistent global bias necessary for the establishment of planar cell polarity?
title_full	Is a persistent global bias necessary for the establishment of planar cell polarity?
title_fullStr	Is a persistent global bias necessary for the establishment of planar cell polarity?
title_full_unstemmed	Is a persistent global bias necessary for the establishment of planar cell polarity?
title_sort	is a persistent global bias necessary for the establishment of planar cell polarity?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/973eee905f4f4617a5a7cf21a628e49a
work_keys_str_mv	AT sabinefischer isapersistentglobalbiasnecessaryfortheestablishmentofplanarcellpolarity AT paulhouston isapersistentglobalbiasnecessaryfortheestablishmentofplanarcellpolarity AT nicholasammonk isapersistentglobalbiasnecessaryfortheestablishmentofplanarcellpolarity AT markusrowen isapersistentglobalbiasnecessaryfortheestablishmentofplanarcellpolarity
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Is a persistent global bias necessary for the establishment of planar cell polarity?

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