Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review

Acute ischemic stroke (AIS) is a common devastating disease that has increased yearly in absolute number of cases since 1990. While mechanical thrombectomy and tissue plasminogen activator (tPA) have proven to be effective treatments, their window-of-efficacy time is very short, leaving many patient...

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Autores principales:	Turner S. Baker, Justin Robeny, Danna Cruz, Alexis Bruhat, Alfred-Marc Iloreta, Anthony Costa, Thomas James Oxley
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	animal studies cerebral blood flow cerebrovascular disease vascular surgery stroke Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9740328999914ddab60ac8700f328355
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spelling	oai:doaj.org-article:9740328999914ddab60ac8700f3283552021-11-18T06:05:10ZStimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review1664-229510.3389/fneur.2021.753182https://doaj.org/article/9740328999914ddab60ac8700f3283552021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.753182/fullhttps://doaj.org/toc/1664-2295Acute ischemic stroke (AIS) is a common devastating disease that has increased yearly in absolute number of cases since 1990. While mechanical thrombectomy and tissue plasminogen activator (tPA) have proven to be effective treatments, their window-of-efficacy time is very short, leaving many patients with no viable treatment option. Over recent years there has been a growing interest in stimulating the facial nerves or ganglions to treat AIS. Pre-clinical studies have consistently demonstrated an increase in collateral blood flow (CBF) following ganglion stimulation, with positive indications in infarct size and neurological scores. Extensive human trials have focused on trans-oral electrical stimulation of the sphenopalatine ganglion, but have suffered from operational limitations and non-significant clinical findings. Regardless, the potential of ganglion stimulation to treat AIS or elongate the window-of-efficacy for current stroke treatments remains extremely promising. This review aims to summarize results from recent trial publications, highlight current innovations, and discuss future directions for the field. Importantly, this review comes after the release of four important clinical trials that were published in mid 2019.Turner S. BakerTurner S. BakerJustin RobenyJustin RobenyDanna CruzDanna CruzAlexis BruhatAlexis BruhatAlfred-Marc IloretaAnthony CostaAnthony CostaThomas James OxleyThomas James OxleyFrontiers Media S.A.articleanimal studiescerebral blood flowcerebrovascular diseasevascular surgerystrokeNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	animal studies cerebral blood flow cerebrovascular disease vascular surgery stroke Neurology. Diseases of the nervous system RC346-429
spellingShingle	animal studies cerebral blood flow cerebrovascular disease vascular surgery stroke Neurology. Diseases of the nervous system RC346-429 Turner S. Baker Turner S. Baker Justin Robeny Justin Robeny Danna Cruz Danna Cruz Alexis Bruhat Alexis Bruhat Alfred-Marc Iloreta Anthony Costa Anthony Costa Thomas James Oxley Thomas James Oxley Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review
description	Acute ischemic stroke (AIS) is a common devastating disease that has increased yearly in absolute number of cases since 1990. While mechanical thrombectomy and tissue plasminogen activator (tPA) have proven to be effective treatments, their window-of-efficacy time is very short, leaving many patients with no viable treatment option. Over recent years there has been a growing interest in stimulating the facial nerves or ganglions to treat AIS. Pre-clinical studies have consistently demonstrated an increase in collateral blood flow (CBF) following ganglion stimulation, with positive indications in infarct size and neurological scores. Extensive human trials have focused on trans-oral electrical stimulation of the sphenopalatine ganglion, but have suffered from operational limitations and non-significant clinical findings. Regardless, the potential of ganglion stimulation to treat AIS or elongate the window-of-efficacy for current stroke treatments remains extremely promising. This review aims to summarize results from recent trial publications, highlight current innovations, and discuss future directions for the field. Importantly, this review comes after the release of four important clinical trials that were published in mid 2019.
format	article
author	Turner S. Baker Turner S. Baker Justin Robeny Justin Robeny Danna Cruz Danna Cruz Alexis Bruhat Alexis Bruhat Alfred-Marc Iloreta Anthony Costa Anthony Costa Thomas James Oxley Thomas James Oxley
author_facet	Turner S. Baker Turner S. Baker Justin Robeny Justin Robeny Danna Cruz Danna Cruz Alexis Bruhat Alexis Bruhat Alfred-Marc Iloreta Anthony Costa Anthony Costa Thomas James Oxley Thomas James Oxley
author_sort	Turner S. Baker
title	Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review
title_short	Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review
title_full	Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review
title_fullStr	Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review
title_full_unstemmed	Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review
title_sort	stimulating the facial nerve to treat ischemic stroke: a systematic review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9740328999914ddab60ac8700f328355
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Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review

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