Metabolic Syndrome Is Associated With Rapid Estimated Glomerular Filtration Rate Decline In A Chinese Community-Based Population
Zhongli Wu, Yimeng Jiang, Jia Jia, Danmei He, Pengfei Sun, Jianping Li, Yong Huo, Fangfang Fan, Yan Zhang Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of ChinaCorrespondence: Fangfang Fan; Yan ZhangDepartment of Cardiology, Peking University First...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/974406ee25d6499095606a9b1edf2bfc |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Zhongli Wu, Yimeng Jiang, Jia Jia, Danmei He, Pengfei Sun, Jianping Li, Yong Huo, Fangfang Fan, Yan Zhang Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of ChinaCorrespondence: Fangfang Fan; Yan ZhangDepartment of Cardiology, Peking University First Hospital, Beijing 100034, People’s Republic of ChinaTel +86 10 8357 5262; +86 10 8357 5728Fax +86 10 6655 1383Email fang9020@126.com; drzhy1108@163.comPurpose: This study aimed to determine the relationship between the metabolic syndrome (MetS) and rapid estimated glomerular filtration rate (eGFR) decline in a Chinese community-based population.Patients and methods: A total of 3108 participants were recruited between December 2011 and July 2014 from an observational study cohort designed for the study of atherosclerotic diseases in Beijing, China. The outcome was a rapid eGFR decline. Subgroup and interaction analyses were performed with respect to a number of covariates.Results: Over a median follow-up period of 2.34 (IQR: 2.29–2.41) years, the overall incidence of rapid eGFR decline was 7.24%. We found that the MetS was significantly associated with the risk of rapid eGFR decline (odds ratio [OR]=1.69, 95% confidence interval [CI]: 1.28–2.23, p<0.001) in a model adjusted for age, sex, and eGFR, and this relationship remained significant after adjustment for smoking, drinking, and low-density lipoprotein-cholesterol (OR=1.78, 95% CI: 1.34–2.35, p<0.001). Waist circumference (OR=1.38, 95% CI: 1.04–1.83, p=0.027), triglycerides (OR=1.40, 95% CI: 1.05–1.86, p=0.022), blood pressure (OR=2.05, 95% CI: 1.49–2.82, p<0.001), and fasting plasma glucose (OR=2.12, 95% CI: 1.57–2.85, p<0.001), but not high-density lipoprotein-cholesterol (OR=1.26, 95% CI: 0.94–1.69, p=0.117), were positively associated with the risk of rapid eGFR decline. Similarly, an increase in the number of MetS components present was associated with an increase in the risk of rapid eGFR decline. Furthermore, this association was modified by smoking status (OR=3.78, 95% CI: 1.68–8.49, p-interaction=0.030).Conclusion: The MetS independently predicted rapid eGFR decline in a Chinese community-based cohort recruited for the study of atherosclerosis. The relationship between the MetS and the risk of rapid eGFR decline was modified by smoking status.Keywords: metabolic abnormalities, estimated glomerular filtration rate, kidney function, atherosclerosis |
|---|