TLRs in COVID-19: How they drive immunopathology and the rationale for modulation

COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within the innate immune system drive the balance between deleterious inflammation and viral clearance. We hypothesize that a divergence between the generation of excessive inflammation through over activation of the...

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Autores principales:	F. Linzee Mabrey, Eric D Morrell, Mark M Wurfel
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/974427168b5e4e37bfe9dcaa25899ffa
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spelling	oai:doaj.org-article:974427168b5e4e37bfe9dcaa25899ffa2021-12-02T07:35:13ZTLRs in COVID-19: How they drive immunopathology and the rationale for modulation1753-42591753-426710.1177/17534259211051364https://doaj.org/article/974427168b5e4e37bfe9dcaa25899ffa2021-10-01T00:00:00Zhttps://doi.org/10.1177/17534259211051364https://doaj.org/toc/1753-4259https://doaj.org/toc/1753-4267COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within the innate immune system drive the balance between deleterious inflammation and viral clearance. We hypothesize that a divergence between the generation of excessive inflammation through over activation of the TLR associated myeloid differentiation primary response (MyD88) pathway relative to the TIR-domain-containing adaptor-inducing IFN-β (TRIF) pathway plays a key role in COVID-19 severity. Both viral elements and damage associated host molecules act as TLR ligands in this process. In this review, we detail the mechanism for this imbalance in COVID-19 based on available evidence, and we discuss how modulation of critical elements may be important in reducing severity of disease.F. Linzee MabreyEric D MorrellMark M WurfelSAGE PublishingarticleImmunologic diseases. AllergyRC581-607ENInnate Immunity, Vol 27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 F. Linzee Mabrey Eric D Morrell Mark M Wurfel TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
description	COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within the innate immune system drive the balance between deleterious inflammation and viral clearance. We hypothesize that a divergence between the generation of excessive inflammation through over activation of the TLR associated myeloid differentiation primary response (MyD88) pathway relative to the TIR-domain-containing adaptor-inducing IFN-β (TRIF) pathway plays a key role in COVID-19 severity. Both viral elements and damage associated host molecules act as TLR ligands in this process. In this review, we detail the mechanism for this imbalance in COVID-19 based on available evidence, and we discuss how modulation of critical elements may be important in reducing severity of disease.
format	article
author	F. Linzee Mabrey Eric D Morrell Mark M Wurfel
author_facet	F. Linzee Mabrey Eric D Morrell Mark M Wurfel
author_sort	F. Linzee Mabrey
title	TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
title_short	TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
title_full	TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
title_fullStr	TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
title_full_unstemmed	TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
title_sort	tlrs in covid-19: how they drive immunopathology and the rationale for modulation
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/974427168b5e4e37bfe9dcaa25899ffa
work_keys_str_mv	AT flinzeemabrey tlrsincovid19howtheydriveimmunopathologyandtherationaleformodulation AT ericdmorrell tlrsincovid19howtheydriveimmunopathologyandtherationaleformodulation AT markmwurfel tlrsincovid19howtheydriveimmunopathologyandtherationaleformodulation
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TLRs in COVID-19: How they drive immunopathology and the rationale for modulation

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