ABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES

Abstract. Polyclonal immunoglobulins G (subclasses 1, 2, 4) from sera of 255 patients and 69 healthy persons were studied by a combined approach using rivanol treatment and affinity chromatography. Enzymatic reactions were carried out according to the methods that we have previously developed and va...

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Autor principal:	E. V. Kunder
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	spondyloarthropathies abzyme activity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/974523bd38b2423986ed96fea66706ee
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spelling	oai:doaj.org-article:974523bd38b2423986ed96fea66706ee2021-11-18T08:03:40ZABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES1563-06252313-741X10.15789/1563-0625-2009-2-3-215-220https://doaj.org/article/974523bd38b2423986ed96fea66706ee2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/305https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Polyclonal immunoglobulins G (subclasses 1, 2, 4) from sera of 255 patients and 69 healthy persons were studied by a combined approach using rivanol treatment and affinity chromatography. Enzymatic reactions were carried out according to the methods that we have previously developed and validated for evaluation of abzyme activity in the patients with different disorders. The levels of DNase, proteolytic BAPNA-amidase (benzoylarginine-p-nitroanilide amidase), and superoxyde dismutase abzyme activity in spondyloarthropathies proved to be significantly higher (p = 0.001), as compared with a control group. Catalase activity of immunoglobulines in the disorders studied was compatible to control levels (p > 0.05). Analysis of relations between abzyme activity and clinical and laboratory signs of the diseases has revealed some significant correlations. Prevalence of abzyme DNAse activity is found in the patients with psoriatic arthritis, as compared to reactive arthritis and ankylosing spondilitis (p < 0.001).E. V. KunderSPb RAACIarticlespondyloarthropathiesabzyme activityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 215-220 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	spondyloarthropathies abzyme activity Immunologic diseases. Allergy RC581-607
spellingShingle	spondyloarthropathies abzyme activity Immunologic diseases. Allergy RC581-607 E. V. Kunder ABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES
description	Abstract. Polyclonal immunoglobulins G (subclasses 1, 2, 4) from sera of 255 patients and 69 healthy persons were studied by a combined approach using rivanol treatment and affinity chromatography. Enzymatic reactions were carried out according to the methods that we have previously developed and validated for evaluation of abzyme activity in the patients with different disorders. The levels of DNase, proteolytic BAPNA-amidase (benzoylarginine-p-nitroanilide amidase), and superoxyde dismutase abzyme activity in spondyloarthropathies proved to be significantly higher (p = 0.001), as compared with a control group. Catalase activity of immunoglobulines in the disorders studied was compatible to control levels (p > 0.05). Analysis of relations between abzyme activity and clinical and laboratory signs of the diseases has revealed some significant correlations. Prevalence of abzyme DNAse activity is found in the patients with psoriatic arthritis, as compared to reactive arthritis and ankylosing spondilitis (p < 0.001).
format	article
author	E. V. Kunder
author_facet	E. V. Kunder
author_sort	E. V. Kunder
title	ABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES
title_short	ABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES
title_full	ABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES
title_fullStr	ABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES
title_full_unstemmed	ABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES
title_sort	abzyme activity of polyclonal immunoglobulins in spondyloarthropathies
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/974523bd38b2423986ed96fea66706ee
work_keys_str_mv	AT evkunder abzymeactivityofpolyclonalimmunoglobulinsinspondyloarthropathies
_version_	1718422494146199552

ABZYME ACTIVITY OF POLYCLONAL IMMUNOGLOBULINS IN SPONDYLOARTHROPATHIES

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