Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells

Satya Prakash, Aleksandra Malgorzata UrbanskaBiomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: There has been an ampl...

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Autores principales:	Satya Prakash, Aleksandra Malgorzata Urbanska
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/97455c0a5da049af98eed22a92df058d
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spelling	oai:doaj.org-article:97455c0a5da049af98eed22a92df058d2021-12-02T04:08:11ZColon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells1177-54751177-5491https://doaj.org/article/97455c0a5da049af98eed22a92df058d2008-09-01T00:00:00Zhttp://www.dovepress.com/colon-targeted-delivery-of-live-bacterial-cell-biotherapeutics-includi-a2287https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Satya Prakash, Aleksandra Malgorzata UrbanskaBiomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: There has been an ample interest in delivery of therapeutic molecules using live cells. Oral delivery has been stipulated as best way to deliver live cells to humans for therapy. Colon, in particular, is a part of gastrointestinal (GI) tract that has been proposed to be an oral targeted site. The main objective of these oral therapy procedures is to deliver live cells not only to treat diseases like colorectal cancer, inflammatory bowel disease, and other GI tract diseases like intestinal obstruction and gastritis, but also to deliver therapeutic molecules for overall therapy in various diseases such as renal failure, coronary heart disease, hypertension, and others. This review provides a comprehensive summary of recent advancement in colon targeted live bacterial cell biotherapeutics. Current status of bacterial cell therapy, principles of artificial cells and its potentials in oral delivery of live bacterial cell biotherapeutics for clinical applications as well as biotherapeutic future perspectives are also discussed in our review.Keywords: biotherapeutics, probiotic, microcapsules, gastrointestinal tract, colon, oral delivery, immobilization, artificial cells, bacterial cells Satya PrakashAleksandra Malgorzata UrbanskaDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 3, Pp 355-378 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Satya Prakash Aleksandra Malgorzata Urbanska Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells
description	Satya Prakash, Aleksandra Malgorzata UrbanskaBiomedical Technology and Cell Therapy Research Laboratory, Departments of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, Quebec, CanadaAbstract: There has been an ample interest in delivery of therapeutic molecules using live cells. Oral delivery has been stipulated as best way to deliver live cells to humans for therapy. Colon, in particular, is a part of gastrointestinal (GI) tract that has been proposed to be an oral targeted site. The main objective of these oral therapy procedures is to deliver live cells not only to treat diseases like colorectal cancer, inflammatory bowel disease, and other GI tract diseases like intestinal obstruction and gastritis, but also to deliver therapeutic molecules for overall therapy in various diseases such as renal failure, coronary heart disease, hypertension, and others. This review provides a comprehensive summary of recent advancement in colon targeted live bacterial cell biotherapeutics. Current status of bacterial cell therapy, principles of artificial cells and its potentials in oral delivery of live bacterial cell biotherapeutics for clinical applications as well as biotherapeutic future perspectives are also discussed in our review.Keywords: biotherapeutics, probiotic, microcapsules, gastrointestinal tract, colon, oral delivery, immobilization, artificial cells, bacterial cells
format	article
author	Satya Prakash Aleksandra Malgorzata Urbanska
author_facet	Satya Prakash Aleksandra Malgorzata Urbanska
author_sort	Satya Prakash
title	Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells
title_short	Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells
title_full	Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells
title_fullStr	Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells
title_full_unstemmed	Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells
title_sort	colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/97455c0a5da049af98eed22a92df058d
work_keys_str_mv	AT satyaprakash colontargeteddeliveryoflivebacterialcellbiotherapeuticsincludingmicroencapsulatedlivebacterialcells AT aleksandramalgorzataurbanska colontargeteddeliveryoflivebacterialcellbiotherapeuticsincludingmicroencapsulatedlivebacterialcells
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Colon-targeted delivery of live bacterial cell biotherapeutics including microencapsulated live bacterial cells

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