Activating newborn neurons suppresses depression and anxiety-like behaviors

It is unclear if there is a causal link between increased neurogenesis and altered affective behaviors in major depressive disorders. Here, the authors show that selectively suppressing the excitability of newborn neurons, without altering neurogenesis, abolishes the antidepressant effects of fluoxe...

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Autores principales: Elif Tunc-Ozcan, Chian-Yu Peng, Yiwen Zhu, Sara R. Dunlop, Anis Contractor, John A. Kessler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/97472875d4a74b7fa186df11b37d1767
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Sumario:It is unclear if there is a causal link between increased neurogenesis and altered affective behaviors in major depressive disorders. Here, the authors show that selectively suppressing the excitability of newborn neurons, without altering neurogenesis, abolishes the antidepressant effects of fluoxetine.