Activating newborn neurons suppresses depression and anxiety-like behaviors

It is unclear if there is a causal link between increased neurogenesis and altered affective behaviors in major depressive disorders. Here, the authors show that selectively suppressing the excitability of newborn neurons, without altering neurogenesis, abolishes the antidepressant effects of fluoxe...

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Autores principales:	Elif Tunc-Ozcan, Chian-Yu Peng, Yiwen Zhu, Sara R. Dunlop, Anis Contractor, John A. Kessler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97472875d4a74b7fa186df11b37d1767
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spelling	oai:doaj.org-article:97472875d4a74b7fa186df11b37d17672021-12-02T14:38:46ZActivating newborn neurons suppresses depression and anxiety-like behaviors10.1038/s41467-019-11641-82041-1723https://doaj.org/article/97472875d4a74b7fa186df11b37d17672019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11641-8https://doaj.org/toc/2041-1723It is unclear if there is a causal link between increased neurogenesis and altered affective behaviors in major depressive disorders. Here, the authors show that selectively suppressing the excitability of newborn neurons, without altering neurogenesis, abolishes the antidepressant effects of fluoxetine.Elif Tunc-OzcanChian-Yu PengYiwen ZhuSara R. DunlopAnis ContractorJohn A. KesslerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elif Tunc-Ozcan Chian-Yu Peng Yiwen Zhu Sara R. Dunlop Anis Contractor John A. Kessler Activating newborn neurons suppresses depression and anxiety-like behaviors
description	It is unclear if there is a causal link between increased neurogenesis and altered affective behaviors in major depressive disorders. Here, the authors show that selectively suppressing the excitability of newborn neurons, without altering neurogenesis, abolishes the antidepressant effects of fluoxetine.
format	article
author	Elif Tunc-Ozcan Chian-Yu Peng Yiwen Zhu Sara R. Dunlop Anis Contractor John A. Kessler
author_facet	Elif Tunc-Ozcan Chian-Yu Peng Yiwen Zhu Sara R. Dunlop Anis Contractor John A. Kessler
author_sort	Elif Tunc-Ozcan
title	Activating newborn neurons suppresses depression and anxiety-like behaviors
title_short	Activating newborn neurons suppresses depression and anxiety-like behaviors
title_full	Activating newborn neurons suppresses depression and anxiety-like behaviors
title_fullStr	Activating newborn neurons suppresses depression and anxiety-like behaviors
title_full_unstemmed	Activating newborn neurons suppresses depression and anxiety-like behaviors
title_sort	activating newborn neurons suppresses depression and anxiety-like behaviors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/97472875d4a74b7fa186df11b37d1767
work_keys_str_mv	AT eliftuncozcan activatingnewbornneuronssuppressesdepressionandanxietylikebehaviors AT chianyupeng activatingnewbornneuronssuppressesdepressionandanxietylikebehaviors AT yiwenzhu activatingnewbornneuronssuppressesdepressionandanxietylikebehaviors AT sarardunlop activatingnewbornneuronssuppressesdepressionandanxietylikebehaviors AT aniscontractor activatingnewbornneuronssuppressesdepressionandanxietylikebehaviors AT johnakessler activatingnewbornneuronssuppressesdepressionandanxietylikebehaviors
_version_	1718390851071115264

Activating newborn neurons suppresses depression and anxiety-like behaviors

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