Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus

Abstract Immune-neuroendocrine phenotypes (INPs) stand for population subgroups differing in immune-neuroendocrine interactions. While mammalian INPs have been characterized thoroughly in rats and humans, avian INPs were only recently described in Coturnix coturnix (quail). To assess the scope of th...

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Autores principales:	F. Nicolas Nazar, Inma Estevez, Silvia G. Correa, Raul H. Marin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/974c0873ed6e47f388cbbfef8ce0ede2
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spelling	oai:doaj.org-article:974c0873ed6e47f388cbbfef8ce0ede22021-12-02T11:52:25ZStress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus10.1038/s41598-017-08733-02045-2322https://doaj.org/article/974c0873ed6e47f388cbbfef8ce0ede22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08733-0https://doaj.org/toc/2045-2322Abstract Immune-neuroendocrine phenotypes (INPs) stand for population subgroups differing in immune-neuroendocrine interactions. While mammalian INPs have been characterized thoroughly in rats and humans, avian INPs were only recently described in Coturnix coturnix (quail). To assess the scope of this biological phenomenon, herein we characterized INPs in Gallus gallus (a domestic hen strain submitted to a very long history of strong selective breeding pressure) and evaluated whether a social chronic stress challenge modulates the individuals’ interplay affecting the INP subsets and distribution. Evaluating plasmatic basal corticosterone, interferon-γ and interleukin-4 concentrations, innate/acquired leukocyte ratio, PHA-P skin-swelling and induced antibody responses, two opposite INP profiles were found: LEWIS-like (15% of the population) and FISCHER-like (16%) hens. After chronic stress, an increment of about 12% in each polarized INP frequency was found at expenses of a reduction in the number of birds with intermediate responses. Results show that polarized INPs are also a phenomenon occurring in hens. The observed inter-individual variation suggest that, even after a considerable selection process, the population is still well prepared to deal with a variety of immune-neuroendocrine challenges. Stress promoted disruptive effects, leading to a more balanced INPs distribution, which represents a new substrate for challenging situations.F. Nicolas NazarInma EstevezSilvia G. CorreaRaul H. MarinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. Nicolas Nazar Inma Estevez Silvia G. Correa Raul H. Marin Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus
description	Abstract Immune-neuroendocrine phenotypes (INPs) stand for population subgroups differing in immune-neuroendocrine interactions. While mammalian INPs have been characterized thoroughly in rats and humans, avian INPs were only recently described in Coturnix coturnix (quail). To assess the scope of this biological phenomenon, herein we characterized INPs in Gallus gallus (a domestic hen strain submitted to a very long history of strong selective breeding pressure) and evaluated whether a social chronic stress challenge modulates the individuals’ interplay affecting the INP subsets and distribution. Evaluating plasmatic basal corticosterone, interferon-γ and interleukin-4 concentrations, innate/acquired leukocyte ratio, PHA-P skin-swelling and induced antibody responses, two opposite INP profiles were found: LEWIS-like (15% of the population) and FISCHER-like (16%) hens. After chronic stress, an increment of about 12% in each polarized INP frequency was found at expenses of a reduction in the number of birds with intermediate responses. Results show that polarized INPs are also a phenomenon occurring in hens. The observed inter-individual variation suggest that, even after a considerable selection process, the population is still well prepared to deal with a variety of immune-neuroendocrine challenges. Stress promoted disruptive effects, leading to a more balanced INPs distribution, which represents a new substrate for challenging situations.
format	article
author	F. Nicolas Nazar Inma Estevez Silvia G. Correa Raul H. Marin
author_facet	F. Nicolas Nazar Inma Estevez Silvia G. Correa Raul H. Marin
author_sort	F. Nicolas Nazar
title	Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus
title_short	Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus
title_full	Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus
title_fullStr	Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus
title_full_unstemmed	Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus
title_sort	stress induced polarization of immune-neuroendocrine phenotypes in gallus gallus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/974c0873ed6e47f388cbbfef8ce0ede2
work_keys_str_mv	AT fnicolasnazar stressinducedpolarizationofimmuneneuroendocrinephenotypesingallusgallus AT inmaestevez stressinducedpolarizationofimmuneneuroendocrinephenotypesingallusgallus AT silviagcorrea stressinducedpolarizationofimmuneneuroendocrinephenotypesingallusgallus AT raulhmarin stressinducedpolarizationofimmuneneuroendocrinephenotypesingallusgallus
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Stress Induced Polarization of Immune-Neuroendocrine Phenotypes in Gallus gallus

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