A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles

2D-thermal proteome profiling (2D-TPP) is a powerful assay for probing interactions of proteins with small molecules in their native context. Here the authors provide a statistical method for false discovery rate controlled analysis for 2D-TPP applications.

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Auteurs principaux: Nils Kurzawa, Isabelle Becher, Sindhuja Sridharan, Holger Franken, André Mateus, Simon Anders, Marcus Bantscheff, Wolfgang Huber, Mikhail M. Savitski
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/974e291ef1154bb3b9d13d00e51b2a9c
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